Benzenethiol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

Base Information

• Chemical Name: Benzenethiol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-
• CAS No.: 141427-16-9
• Molecular Formula: C12H20OSSi
• Molecular Weight: 240.442
• DSSTox Substance ID: DTXSID40470829
• Wikidata: Q82299005
• Mol file: 141427-16-9.mol

Synonyms:Benzenethiol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-;141427-16-9;SCHEMBL2475790;4-t-butyldimethylsiloxythiophenol;DTXSID40470829;IKJYAMWXLXVBDG-UHFFFAOYSA-N;4-{[tert-butyl(dimethyl)silyl]oxy}benzenethiol;4-[(tert-butyldimethylsilyl)oxy]benzene-1-thiol;4-{[tert-butyl(dimethyl)silyl]oxy} benzenethiol;EN300-45210417

Chemical Property of Benzenethiol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

Chemical Property:

• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 240.10041297
• Heavy Atom Count: 15
• Complexity: 202

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C)(C)OC1=CC=C(C=C1)S

Technology Process of Benzenethiol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

There total 1 articles about Benzenethiol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

bis<4-(tert-butyldimethylsiloxy)phenyl> disulfide (137897-98-4) → 4-{[tert-butyl(dimethyl)silyl]oxy}benzenethiol (141427-16-9)

Guidance literature:

With hydrogen; rhodium hydrido (PEt₃)3 complex; In toluene; for 0.5h; Heating;

DOI:10.1016/j.tetlet.2005.06.169

Reference yield: 70.0%

4-{[tert-butyl(dimethyl)silyl]oxy}benzenethiol (141427-16-9) + ethyl bromoacetate (105-36-2) → C16H26O3SSi

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b03852

Reference yield:

4-{[tert-butyl(dimethyl)silyl]oxy}benzenethiol (141427-16-9) + 1,1-dimethylethyl [(6-iodo-4-{[3-(methyloxy)phenyl]amino}-3-quinolinyl)carbonyl]carbamate (801315-72-0) → 6-[(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)thio]-4-[(3-methoxyphenyl)amino]quinoline-3-carboxamide (801315-73-1)

Guidance literature:

With potassium tert-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis[2-(diphenylphosphino)phenyl] ether; In toluene; at 106 ℃; for 18h;

upstream raw materials:

bis<4-(tert-butyldimethylsiloxy)phenyl> disulfide

Downstream raw materials:

6-[(4-{[tert-butyl(dimethyl)silyl]oxy}phenyl)thio]-4-[(3-methoxyphenyl)amino]quinoline-3-carboxamide

2-{4-[(t-butyldimethylsilyl)oxy]phenylthio }-5,7-dihydroxy-6-methoxychromone