(R)-2-({(S)-1-[(2S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxyoxalyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid benzyl ester

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Chemical Name:(R)-2-({(S)-1-[(2S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxyoxalyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid benzyl ester
CAS No.:139300-56-4
Molecular Formula:C₃₂H₃₅N₅O₈
Molecular Weight:617.659
Hs Code.:

(R)-2-({(S)-1-[(2S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxyoxalyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid benzyl ester

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Chemical Property of (R)-2-({(S)-1-[(2S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxyoxalyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid benzyl ester

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Technology Process of (R)-2-({(S)-1-[(2S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxyoxalyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid benzyl ester

There total 4 articles about (R)-2-({(S)-1-[(2S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxyoxalyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 139300-56-4
(R)-2-({(S)-1-[(2S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxyoxalyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl phosphorocyanidate, triethylamine

2: HCl/AcOEt

With hydrogenchloride; diethyl cyanophosphonate; ethyl acetate; triethylamine;
DOI:10.1248/cpb.39.3091

Reference yield:

: 139300-61-1
Boc-Pro-D-Phe-OBzl

: 139300-56-4
(R)-2-({(S)-1-[(2S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxyoxalyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HCl/AcOEt

With hydrogenchloride; ethyl acetate;
DOI:10.1248/cpb.39.3091

Reference yield:

: 28607-46-7
(R)-phenylalanine benzyl ester p-toluenosulfonate

: 139300-56-4
(R)-2-({(S)-1-[(2S,5R)-5-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxyoxalyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl phosphorocyanidate, triethylamine

2: HCl/AcOEt

With hydrogenchloride; diethyl cyanophosphonate; ethyl acetate; triethylamine;
DOI:10.1248/cpb.39.3091