28607-46-7

Usage

Uses

Used in Organic Chemistry Research:
H-D-PHE-OBZL P-TOSYLATE is used as a synthetic intermediate for the preparation of peptide-based compounds. Its tosylate group provides a protecting group for the carboxylic acid function, allowing for selective deprotection and further manipulation of the molecule during peptide synthesis.
Used in Medicinal Chemistry Research:
H-D-PHE-OBZL P-TOSYLATE is used as a building block in the development of pharmaceuticals. Its unique structure and protecting group enable the synthesis of complex peptide-based drugs with specific therapeutic properties.
Used in Peptide Synthesis:
H-D-PHE-OBZL P-TOSYLATE is used as a protected amino acid in the synthesis of peptides. The tosylate group protects the carboxylic acid function, allowing for the stepwise addition of other amino acids to form the desired peptide sequence.
Used in Drug Development:
H-D-PHE-OBZL P-TOSYLATE is used as a key component in the design and synthesis of novel drugs. Its versatility in peptide synthesis allows for the creation of drugs with specific targeting and therapeutic properties, potentially leading to more effective treatments for various diseases.

InChI:InChI=1/C16H17NO2.C7H8O3S/c17-15(11-13-7-3-1-4-8-13)16(18)19-12-14-9-5-2-6-10-14;1-6-2-4-7(5-3-6)11(8,9)10/h1-10,15H,11-12,17H2;2-5H,1H3,(H,8,9,10)/t15-;/m1./s1

Upstream product

• 673-06-3 D-(R)-phenylalanine 
• 104-15-4 toluene-4-sulfonic acid 
• 100-51-6 benzyl alcohol 

Downstream Products

• 139300-61-1 Boc-Pro-D-Phe-OBzl 
• 193810-34-3 (R)-2-(Biphenyl-4-sulfonylamino)-3-phenyl-propionic acid benzyl ester 
• 93397-22-9 Boc-L-Phe-D-Phe-OH 
• 139300-58-6 (R)-2-({(S)-1-[(2S,5R)-5-(6-Amino-purin-9-yl)-tetrahydro-furan-2-ylmethoxyoxalyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid benzyl ester 

Relevant academic research and scientific papers

Mortiamides A-D, Cyclic Heptapeptides from a Novel Mortierella sp. Obtained from Frobisher Bay

Four new cyclic heptapeptides, mortiamides A-D (1-4), were obtained from a novel Mortierella sp. isolate obtained from marine sediment collected from the intertidal zone of Frobisher Bay, Nunavut, Canada. The structures of the compounds were elucidated by NMR spectroscopy and tandem mass spectrometry. The absolute configurations of the amino acids were determined using Marfey's method. Localization of l and d amino acids within each compound was ascertained by retention time comparison of the partial hydrosylate products of each compound to synthesized dipeptide standards using LC-HRMS. Compounds 1-4 did not exhibit any significant antimicrobial or cytotoxic activity.

Effect of stereochemistry on the clearance mechanism of 111in(III)- LABELED D- or L-benzyldiethylenetriaminepentaacetic acid

The diethylenetriaminepentaacetic acid (DTPA) derivatives L-Bn-DTPA and D-Bn-DTPA were synthesized and radiolabeled with 111In3+. The uptake and clearance of the compounds were determined through biodistribution and excretion studies in Wistar rats. Both isomers readily cleared from the animal. The D isomer showed relatively high kidney uptake and predominately renal clearance. The L isomer showed substantial kidney and liver uptake with equal biliary and renal clearance. Clearance was also evaluated in TR- Wistar rats, which are defective in the liver canalicular multispecific organic anion transporter (cMOAT) protein. cMOAT mediates hepatobiliary clearance of many organic anions. Both compounds were excreted through the urine in TR- Wistar rats, suggesting that cMOAT is important in the clearance of the compounds from the liver.