1-(METHYLSULFONYL)PIPERIDIN-4-OL

Base Information

• Chemical Name: 1-(METHYLSULFONYL)PIPERIDIN-4-OL
• CAS No.: 141482-19-1
• Molecular Formula: C6H13NO3S
• Molecular Weight: 179.24
• Hs Code.: 2935009090
• Mol file: 141482-19-1.mol

Synonyms:1-(Methylsulfonyl)piperidin-4-ol;4-hydroxy-1-(methanesulfonyl)-piperidine;1-methanesulphonyl-piperidin-4-ol;1-(methylsulfonyl)-4-piperidinol;N-(methanesulfonyl)-4-piperidinol;4-hydroxy-1-methylsulfonylpiperidine;

Chemical Property of 1-(METHYLSULFONYL)PIPERIDIN-4-OL

Chemical Property:

• Boiling Point: 319.9±52.0 °C(Predicted)
• PKA: 14.51±0.20(Predicted)
• PSA: 65.99000
• Density: 1.33±0.1 g/cm3(Predicted)
• LogP: 0.42140
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1-(Methylsulfonyl)piperidin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(METHYLSULFONYL)PIPERIDIN-4-OL

There total 2 articles about 1-(METHYLSULFONYL)PIPERIDIN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

4-HYDROXYPIPERIDINE (5382-16-1) + methanesulfonyl chloride (124-63-0) → 4-hydroxy-1-methylsulfonylpiperidine (141482-19-1)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 1.16667h;

Reference yield:

methanesulfonyl chloride (124-63-0) + 2-methylpropan-2-yl 4-(acetyloxy)piperidine-1-carboxylate (850452-53-8) → 4-hydroxy-1-methylsulfonylpiperidine (141482-19-1)

Guidance literature:

2-methylpropan-2-yl 4-(acetyloxy)piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

With triethylamine; In dichloromethane; at 0 - 20 ℃;

methanesulfonyl chloride; In dichloromethane; at 0 - 20 ℃; for 15h;

Reference yield: 43.0%

4-hydroxy-1-methylsulfonylpiperidine (141482-19-1) + 2-amino-3,4-difluoronitro-benzene (211693-73-1) → 3-fluoro-4-{[1-(methylsulfonyl)piperidin-4-yl]oxy}benzene-1,2-diamine

Guidance literature:

4-hydroxy-1-methylsulfonylpiperidine; With sodium hydride; In tetrahydrofuran; for 0.333333h;

2-amino-3,4-difluoronitro-benzene; In tetrahydrofuran; at 70 ℃;

With palladium 10% on activated carbon; hydrogen; In ethanol;

upstream raw materials:

4-HYDROXYPIPERIDINE

methanesulfonyl chloride

2-methylpropan-2-yl 4-(acetyloxy)piperidine-1-carboxylate

Downstream raw materials:

N-(4-fluorophenyl)-N-isobutyl-4-(1-methanesulfonylpiperidin-4-yloxy)benzenesulfonamide

N-(4-fluorophenyl)-N-isobutyl-6-((1-(methylsulfonyl)piperidin-4-yl)oxy)pyridine-3-sulfonamide

N-(2-fluorophenyl)-N-isobutyl-4-(1-methanesulfonylpiperidin-4-yloxy)benzenesulfonamide

N-isobutyl-4-(1-methanesulfonylpiperidin-4-yloxy)-N-(2-trifluoromethylbenzyl)benzenesulfonamide

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