Hydrazinecarboxylic acid, [2-(4-chlorophenyl)-1-ethoxyethylidene]-, ethyl ester

Base Information

• Chemical Name: Hydrazinecarboxylic acid, [2-(4-chlorophenyl)-1-ethoxyethylidene]-, ethyl ester
• CAS No.: 141525-15-7
• Molecular Formula: C13H17ClN2O3
• Molecular Weight: 284.743
• Mol file: 141525-15-7.mol

Synonyms:

Chemical Property of Hydrazinecarboxylic acid, [2-(4-chlorophenyl)-1-ethoxyethylidene]-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Hydrazinecarboxylic acid, [2-(4-chlorophenyl)-1-ethoxyethylidene]-, ethyl ester

There total 2 articles about Hydrazinecarboxylic acid, [2-(4-chlorophenyl)-1-ethoxyethylidene]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

ethyl 2-(4-chlorophenyl)acetimidate hydrochloride (43002-66-0) + ethylhydrazine carboxylate (4114-31-2) → ethyl 2-[2-(4-chlorophenyl)-1-ethoxyethylidene]hydrazinecarboxylate (141525-15-7)

Guidance literature:

In ethanol; for 6h; Cooling with ice;

DOI:10.1007/s10593-015-1714-5

Reference yield:

p-chlorobenzyl cyanide (140-53-4) → ethyl 2-[2-(4-chlorophenyl)-1-ethoxyethylidene]hydrazinecarboxylate (141525-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 0 - 5 °C

2: ethanol / 6 h / Cooling with ice

With hydrogenchloride; In ethanol;

DOI:10.1007/s10593-015-1714-5

Reference yield: 88.0%

(4-aminophenyl)(phenyl)methanone (1137-41-3,444317-48-0) + ethyl 2-[2-(4-chlorophenyl)-1-ethoxyethylidene]hydrazinecarboxylate (141525-15-7) → 5-(4-chlorobenzyl)-4-(4-benzoylphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (1426434-72-1)

Guidance literature:

In neat (no solvent); at 150 ℃; for 0.05h; Microwave irradiation; Green chemistry;

DOI:10.1080/00397911.2011.632831

upstream raw materials:

ethyl 2-(4-chlorophenyl)acetimidate hydrochloride

ethylhydrazine carboxylate

p-chlorobenzyl cyanide

Downstream raw materials:

N'-{2-(4-Chloro-phenyl)-1-[(Z)-hydroxyimino]-ethyl}-hydrazinecarboxylic acid ethyl ester

4-amino-3-(p-chlorobenzyl)-1H-1,2,4-triazol-5-one

5-(4-Chloro-benzyl)-4-hydroxy-2,4-dihydro-[1,2,4]triazol-3-one

3-[5'-(4''-chlorobenzyl)-2',4'-dihydro-1',2',4'-triazol-3'-one-4'-yl]iminoisatin

Refernces