N-(4-methoxyphenyl)-5-nitrofuran-2-carboxamide

Base Information

• Chemical Name: N-(4-methoxyphenyl)-5-nitrofuran-2-carboxamide
• CAS No.: 14170-83-3
• Molecular Formula: C12H10N2O5
• Molecular Weight: 262.222
• DSSTox Substance ID: DTXSID001329910
• ChEMBL ID: CHEMBL187263
• Mol file: 14170-83-3.mol

Synonyms:N-(4-methoxyphenyl)-5-nitrofuran-2-carboxamide;MLS001210091;5-Nitro-furan-2-carboxylic acid (4-methoxy-phenyl)-amide;SMR000513391;N-(4-methoxyphenyl)-5-nitro-furan-2-carboxamide;Oprea1_173604;Oprea1_777361;14170-83-3;CHEMBL187263;cid_774010;SCHEMBL6427130;BDBM65582;DTXSID001329910;HMS2813O23;STK021536;AKOS000668798;CCG-105104;N-(4-methoxyphenyl)-5-nitro-2-furamide;EU-0036276;N-(4-methoxyphenyl)-5-nitro-2-furancarboxamide;2-Furancarboxamide, N-(4-methoxyphenyl)-5-nitro-;SR-01000414014;SR-01000414014-1

Chemical Property of N-(4-methoxyphenyl)-5-nitrofuran-2-carboxamide

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 262.05897142
• Heavy Atom Count: 19
• Complexity: 336

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NC(=O)C2=CC=C(O2)[N+](=O)[O-]

Technology Process of N-(4-methoxyphenyl)-5-nitrofuran-2-carboxamide

There total 5 articles about N-(4-methoxyphenyl)-5-nitrofuran-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-nitro-2-furoic acid (645-12-5) + 4-methoxy-aniline (104-94-9) → N-(4-methoxyphenyl)-5-nitrofuran-2-carboxamide (14170-83-3)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 14h;

DOI:10.1021/jm049972y

Reference yield: 85.0%

5-nitro-2-furan carboxylic acid + 4-methoxy-aniline (104-94-9) → N-(4-methoxyphenyl)-5-nitrofuran-2-carboxamide (14170-83-3)

Guidance literature:

With dmap; In N,N-dimethyl-formamide;

Reference yield:

5-nitrofuran-2-carboxylic chloride (25084-14-4) + 4-methoxy-aniline (104-94-9) → N-(4-methoxyphenyl)-5-nitrofuran-2-carboxamide (14170-83-3)

Guidance literature:

With pyridine; diethyl ether;

upstream raw materials:

5-nitrofuran-2-carboxylic chloride

4-methoxy-aniline

5-nitro-2-furoic acid

Downstream raw materials:

1-(4-methoxy-phenyl)-5-(5-nitro-furan-2-yl)-1H-tetrazole