2-Chloro-N-(5-nitro-thiazol-2-yl)-acetaMide, 98+% C5H4ClN3O3S, MW: 221.62

Base Information

• Chemical Name: 2-Chloro-N-(5-nitro-thiazol-2-yl)-acetaMide, 98+% C5H4ClN3O3S, MW: 221.62
• CAS No.: 50772-59-3
• Molecular Formula: C5H4 Cl N3 O3 S
• Molecular Weight: 221.624
• Mol file: 50772-59-3.mol

Synonyms:Thiazole,2-(2-chloroacetamido)-5-nitro- (7CI); NSC 149458

Chemical Property of 2-Chloro-N-(5-nitro-thiazol-2-yl)-acetaMide, 98+% C5H4ClN3O3S, MW: 221.62

Chemical Property:

• Melting Point: 146-147℃
• PSA: 116.05000
• Density: 1.725g/cm³
• LogP: 1.82480

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-N-(5-nitro-thiazol-2-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Chloro-N-(5-nitro-thiazol-2-yl)-acetaMide, 98+% C5H4ClN3O3S, MW: 221.62

There total 1 articles about 2-Chloro-N-(5-nitro-thiazol-2-yl)-acetaMide, 98+% C5H4ClN3O3S, MW: 221.62 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-amino-5-nitro-1,3-thiazole (121-66-4,176384-36-4,8023-00-5) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(5-nitrothiazol-2-yl)acetamide (50772-59-3)

Guidance literature:

With triethylamine; In acetonitrile; at 0 - 20 ℃; for 4h;

Reference yield: 88.0%

2-chloro-N-(5-nitrothiazol-2-yl)acetamide (50772-59-3) + 5-(4-(trifluoromethyl)phenyl)amino-1,3,4-thiadiazole-2(3H)-thione → N-(5-nitrothiazol-2-yl)-2-((5-((4-(trifluoromethyl)phenyl)amino)-1,3,4-thiadiazol-2-yl)thio)acetamide

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 8h;

DOI:10.3390/molecules23010059

Reference yield: 66.0%

2-chloro-N-(5-nitrothiazol-2-yl)acetamide (50772-59-3) + N-(4-chlorobenzhydryl)piperazine (303-26-4) → 2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-N-(5-nitrothiazol-2-yl)acetamide

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1128/AAC.02006-15

upstream raw materials:

2-amino-5-nitro-1,3-thiazole

chloroacetyl chloride

Downstream raw materials:

(Z)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-N-(5-nitrothiazol-2-yl)acetamide

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