Methanone, phenyl(tetrahydro-2-furanyl)-

Base Information

• Chemical Name: Methanone, phenyl(tetrahydro-2-furanyl)-
• CAS No.: 141957-79-1
• Molecular Formula: C11H12O2
• Molecular Weight: 176.215
• DSSTox Substance ID: DTXSID40471639
• Nikkaji Number: J3.313.916K
• Mol file: 141957-79-1.mol

Synonyms:141957-79-1;Phenyl(tetrahydrofuran-2-yl)methanone;Methanone, phenyl(tetrahydro-2-furanyl)-;oxolan-2-yl-phenylmethanone;DTXSID40471639;phenyl(tetrahydro-2-furanyl)methanone;AKOS009338880

Chemical Property of Methanone, phenyl(tetrahydro-2-furanyl)-

Chemical Property:

• PSA: 26.30000
• LogP: 2.04830
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 176.083729621
• Heavy Atom Count: 13
• Complexity: 183

Purity/Quality:

Phenyl(tetrahydrofuran-2-yl)methanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(OC1)C(=O)C2=CC=CC=C2

Technology Process of Methanone, phenyl(tetrahydro-2-furanyl)-

There total 19 articles about Methanone, phenyl(tetrahydro-2-furanyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-(tert-butylperoxy)-1-phenylpentan-1-one (1592933-87-3) → phenyl(tetrahydrofuran-2-yl)methanone (141957-79-1)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; Reagent/catalyst; Inert atmosphere;

DOI:10.1021/ja5026276

Reference yield: 91.0%

2-phenyltetrahydropyran (4203-44-5) → phenyl(tetrahydrofuran-2-yl)methanone (141957-79-1)

Guidance literature:

With p-nitrobenzenesulfonamide; water; hydrogen bromide; oxygen; sodium nitrite; In acetonitrile; at 0 - 50 ℃; for 6.5h; under 760.051 Torr; Temperature; Darkness;

DOI:10.1021/acs.orglett.8b02488

Reference yield: 91.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + 1-benzoylpyrrolidine-2,5-dione (6343-27-7) → phenyl(tetrahydrofuran-2-yl)methanone (141957-79-1)

Guidance literature:

With (1,2-dimethoxyethane)dichloronickel(II); [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; potassium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine; In benzene; at 20 ℃; for 16h; Irradiation; Inert atmosphere;

DOI:10.1002/anie.202004441

upstream raw materials:

(furan-2-yl)(phenyl)methanone

carbon dioxide

tert.-butyl lithium

2-Tetrahydrofuryl-Li

Downstream raw materials:

C₁₆H₂₀O₃

C₁₇H₂₀O₅

C₁₇H₂₀O₅

threo-phenyl(tetrahydrofuran-2-yl)methanol