2-Benzoyl-5-fluorobenzoic acid

Base Information

• Chemical Name: 2-Benzoyl-5-fluorobenzoic acid
• CAS No.: 142153-72-8
• Molecular Formula: C₁₄H₉FO₃
• Molecular Weight: 244.222
• Mol file: 142153-72-8.mol

Synonyms:

Chemical Property of 2-Benzoyl-5-fluorobenzoic acid

Chemical Property:

• Boiling Point: 440.6±35.0 °C(Predicted)
• PKA: 3.20±0.10(Predicted)
• PSA: 0.00000
• Density: 1.325±0.06 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

2-Benzoyl-5-fluorobenzoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzoyl-5-fluorobenzoic acid

There total 3 articles about 2-Benzoyl-5-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-fluorobenzoic acid (455-38-9) + Benzoylformic acid (611-73-4) → 5-fluoro-2-(phenylcarbonyl)benzoic acid (142153-72-8)

Guidance literature:

With palladium(II) trifluoroacetate; silver carbonate; In 1,2-dimethoxyethane; at 150 ℃; for 24h; chemoselective reaction; Sealed tube;

DOI:10.1021/ol400919u

Reference yield: 33.0%

4-fluorophthalic anhydride (319-03-9) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 5-fluoro-2-(phenylcarbonyl)benzoic acid (142153-72-8) + 4-fluoro-2-(phenylcarbonyl)benzoic acid (33184-59-7)

Guidance literature:

4-fluorophthalic anhydride; benzene; With aluminum (III) chloride; at 0 - 20 ℃; for 40h;

With water; at 0 ℃;

DOI:10.1016/j.bmc.2011.06.059

Reference yield:

→ 5-fluoro-2-(phenylcarbonyl)benzoic acid (142153-72-8)

Guidance literature:

upstream raw materials:

4-fluorophthalic anhydride

benzene

3-fluorobenzoic acid

Benzoylformic acid