319-03-9

Basic information

• Product Name: 5-Fluoro-1,3-isobenzofurandione
• Synonyms: 5-fluoro-3-isobenzofurandione;5-Fluoro-isobenzofuran-1,3-dione;5-FLUORO-BENZO[C]FURAN-1,3-DIONE;5-Fluoro-1,3-isobenzofurandione;5-FLUORO-2-BENZOFURAN-1,3-DIONE;4-FLUOROPHTHALIC ACID ANHYDRIDE;4-FLUOROPHTHALIC ANHYDRIDE;4-FLUOROBENZENE-1,2-DICARBOXYLIC ANHYDRIDE
• CAS NO: 319-03-9
• Molecular Formula: C₈H₃FO₃
• Molecular Weight: 166.11
• EINECS: 1312995-182-4
• Product Categories: Phthalic Acids, Esters and Derivatives;API intermediates;Carbonyl Compounds;Carboxylic Acid Anhydrides;Organic Building Blocks;Heterocycles
• Mol File: 319-03-9.mol
• Article Data: 12

Chemical Properties

• Melting Point: 75-79 °C(lit.)
• Boiling Point: 148°C 20mm
• Flash Point: >93°C
• Appearance: white to light yellow crystal powder
• Density: 1.55
• Vapor Pressure: 0.000893mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility: Soluble in sodium hydroxide.
• Sensitive: Moisture Sensitive
• BRN: 131281
• CAS DataBase Reference: 5-Fluoro-1,3-isobenzofurandione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-1,3-isobenzofurandione(319-03-9)
• EPA Substance Registry System: 5-Fluoro-1,3-isobenzofurandione(319-03-9)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-42/43
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 2
• TSCA: Yes
• HazardClass: IRRITANT, MOISTURE SENSITIVE
• PackingGroup: Ⅲ
• Hazardous Substances Data: 319-03-9(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

Uses

Different sources of media describe the Uses of 319-03-9 differently. You can refer to the following data:
1. 4-Fluorophthalic anhydride is used in the preparation of 5-fluoro-2-pyridin-3-ylmethyl-isoindole-1,3-dione by reacting with C-pyridin-3-yl-methylamine.
2. 4-Fluorophthalic anhydride can be used as a reactant to prepare: 4-amino substituted phthalimides applicable as potential fluorescent probes and fluorescent bioactive compounds. 4,4′-bis(4-fluorophthalimido)diphenyl ether monomer, which is used in the synthesis of cardo polymers via nucleophilic substitution polymerization reaction.Asymmetric polyimides by a solution polycondensation reaction.

General Description

4-Fluorophthalic anhydride is a fluorinated building block commonly used in chemical synthesis for the preparation of polyimide, pesticides, herbicides, and fungicides. It can be synthesized by treating 4-chlorophthalic anhydride with potassium fluoride.

InChI:InChI=1/C8H3FO3/c9-4-1-2-5-6(3-4)8(11)12-7(5)10/h1-3H

Upstream product

• 157170-46-2 4-chloro-3,6-dihydrophthalic anhydride 
• 157170-52-0 4-chloro-2-bromo-1,2,3,6-tetrahydrophthalic anhydride 
• 157170-47-3 4-chloro-l-bromo-1,2,3,6-tetrahydrophthalic anhydride 
• 120-82-1 1,2,4-Trichlorobenzene 
• 5466-84-2 4-nitrophthalic anhydride 
• 320-96-7 4-fluoro-phthalic acid diethyl ester 
• 320-97-8 4-fluorobenzene-1,2-dicarboxylic acid 
• 118-45-6 4-chlorophthalic anhydride 

Downstream Products

• 62558-08-1 4-fluoro-2-(hydroxymethyl)benzyl alcohol 
• 221128-52-5 2-(4-tert-butyl-phenyl)-5-fluoro-isoindole-1,3-dione 
• 63197-16-0 5-fluoro-2-phenylisoindoline-1,3-dione 
• 444717-62-8 4-fluoro-N-(4-nitrophenyl)phthalimide 
• 1379192-12-7 C₉H₇FO₄ 
• 217493-05-5 2-Cyclohexyl-2,3-dihydro-5-fluoro-6-(piperazin-1-yl)-1H-isoindol-1-one 
• 110706-50-8 dimethyl 4-fluorophthalate 
• 1823-59-2 4,4'-oxydiphthalic dianhydride 
• 122590-10-7 4-(2',6'-Dimethylphenoxy) Phthalic Anhydride 
• 122590-15-2 4-(4'-bromophenoxy)phthalic anhydride 
• 58230-72-1 N-(4-nitro-o-tolyl)-4-fluorophthalimide 
• 1022984-06-0 5-fluoro-2-(4-dimethylaminophenyl)isoindol-1,3-dione 
• 1022984-10-6 C₁₇H₁₅FN₂O₃ 
• 33184-59-7 4-fluoro-2-(phenylcarbonyl)benzoic acid 

Relevant articles and documents

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Synthesis of 4-substituted phthalic anhydrides

Disclosed is a method of making a 4-substituted phthalic anhydride. A halomaleic (including halofumaric anhydride (or the acid or ester thereof) is made by the reaction of-maleic anhydride with chlorine or bromine. The halomaleic anhydride is reacted with a conjugated diene to form a first cycloadduct having the formula STR1 The first cycloadduct is heated to eliminate HX and produce a second cycloadduct having the formula STR2 The second cyclo adduct is dehydrogenated to produce a 4substituted phthalic anhydride which has the formula STR3 where R1, R2, and R4 are preferably H and R3 is preferably Cl or F.