1H-Pyrrole-2-carboxylic acid, 1-[2-[[4-[(2-butyl-4-methyl-1H-benzimidazol-1-yl)methyl]phenyl]amino]-2- oxo-1-(phenylmethyl)ethyl]-, methyl ester, (S)-

Base Information

• Chemical Name: 1H-Pyrrole-2-carboxylic acid, 1-[2-[[4-[(2-butyl-4-methyl-1H-benzimidazol-1-yl)methyl]phenyl]amino]-2- oxo-1-(phenylmethyl)ethyl]-, methyl ester, (S)-
• CAS No.: 142219-19-0
• Molecular Formula: C34H36N4O3
• Molecular Weight: 548.685
• Mol file: 142219-19-0.mol

Synonyms:

Chemical Property of 1H-Pyrrole-2-carboxylic acid, 1-[2-[[4-[(2-butyl-4-methyl-1H-benzimidazol-1-yl)methyl]phenyl]amino]-2- oxo-1-(phenylmethyl)ethyl]-, methyl ester, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrole-2-carboxylic acid, 1-[2-[[4-[(2-butyl-4-methyl-1H-benzimidazol-1-yl)methyl]phenyl]amino]-2- oxo-1-(phenylmethyl)ethyl]-, methyl ester, (S)-

There total 7 articles about 1H-Pyrrole-2-carboxylic acid, 1-[2-[[4-[(2-butyl-4-methyl-1H-benzimidazol-1-yl)methyl]phenyl]amino]-2- oxo-1-(phenylmethyl)ethyl]-, methyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-butyl-4-methyl-benzimidazole (77303-08-3) → (S) Methyl 1-[2-[[4-[(2-butyl-4-methyl-1H-benzimidazol-1-yl)methyl]phenyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-1H-pyrrole-2-carboxylate (142219-19-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 60 percent NaH / 1.) DMF, RT, 2.) DMF, 6h

2: H₂ / Raney Ni / tetrahydrofuran / 23 °C / 2585.7 Torr

3: (CH₃)3CCOCl, DMAP / tetrahydrofuran

With dmap; hydrogen; pivaloyl chloride; sodium hydride; nickel; In tetrahydrofuran;

DOI:10.1021/jm00064a007

Reference yield:

2-butyl-4-methyl-1-<(4-nitrophenyl)methyl>-1H-benzimidazole (142219-33-8) → (S) Methyl 1-[2-[[4-[(2-butyl-4-methyl-1H-benzimidazol-1-yl)methyl]phenyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-1H-pyrrole-2-carboxylate (142219-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Raney Ni / tetrahydrofuran / 23 °C / 2585.7 Torr

2: (CH₃)3CCOCl, DMAP / tetrahydrofuran

With dmap; hydrogen; pivaloyl chloride; nickel; In tetrahydrofuran;

DOI:10.1021/jm00064a007

Reference yield:

1-bromomethyl-4-nitro-benzene (100-11-8) → (S) Methyl 1-[2-[[4-[(2-butyl-4-methyl-1H-benzimidazol-1-yl)methyl]phenyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-1H-pyrrole-2-carboxylate (142219-19-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 60 percent NaH / 1.) DMF, RT, 2.) DMF, 6h

2: H₂ / Raney Ni / tetrahydrofuran / 23 °C / 2585.7 Torr

3: (CH₃)3CCOCl, DMAP / tetrahydrofuran

With dmap; hydrogen; pivaloyl chloride; sodium hydride; nickel; In tetrahydrofuran;

DOI:10.1021/jm00064a007

upstream raw materials:

(S)-2-(methoxycarbonyl)-α-(phenylmethyl)-1H-pyrrole-1-acetic acid

4-<(2-butyl-4-methyl-1H-benzimidazol-1-yl)methyl>benzenamine

2,5-dimethoxy-tetrahydro-furan-2-carboxylic acid methyl ester

L-phenylalanine