1H-Benzimidazole,2-butyl-4-methyl-(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole,2-butyl-4-methyl-(9CI)
• CAS No.: 77303-08-3
• Molecular Formula: C12H16 N2
• Molecular Weight: 188.27
• Mol file: 77303-08-3.mol

Synonyms:1H-Benzimidazole,2-butyl-4-methyl- (9CI); 2-Butyl-4-methylbenzimidazole;2-n-Butyl-4-methylbenzimidazole

Chemical Property of 1H-Benzimidazole,2-butyl-4-methyl-(9CI)

Chemical Property:

• PSA: 28.68000
• LogP: 3.21390

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole,2-butyl-4-methyl-(9CI)

There total 3 articles about 1H-Benzimidazole,2-butyl-4-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

trimethyl orthovalerate (13820-09-2) + 3-methyl-1,2-benzenediamine (2687-25-4) → 2-butyl-4-methyl-benzimidazole (77303-08-3)

Guidance literature:

With zirconium(IV) oxychloride octahydrate; for 0.116667h; Microwave irradiation;

Reference yield:

ethyl acetate n-hexane + 3-methyl-1,2-benzenediamine (2687-25-4) + valeric acid (109-52-4) → 2-butyl-4-methyl-benzimidazole (77303-08-3)

Guidance literature:

With PPA;

Reference yield:

3-methyl-1,2-benzenediamine (2687-25-4) + valeric acid (109-52-4) → 2-Butyl-7-methyl-1H-benzoimidazole (77303-08-3)

Guidance literature:

With trichlorophosphate;

DOI:10.1021/jm00077a007

upstream raw materials:

trimethyl orthovalerate

3-methyl-1,2-benzenediamine

valeric acid

Downstream raw materials:

4'-(2-Butyl-4-methyl-benzoimidazol-1-ylmethyl)-biphenyl-2-carboxylic acid tert-butyl ester

(S) Methyl 1-[2-[[4-[(2-butyl-4-methyl-1H-benzimidazol-1-yl)methyl]phenyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-1H-pyrrole-2-carboxylate

4-<(2-butyl-4-methyl-1H-benzimidazol-1-yl)methyl>benzenamine

2-butyl-4-methyl-1-<(4-nitrophenyl)methyl>-1H-benzimidazole