(2-{2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-tritylsulfanyl-propionylamino]-4-methylsulfanyl-butyrylamino}-4-methyl-pentanoylamino)-acetic acid

Base Information

• Chemical Name: (2-{2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-tritylsulfanyl-propionylamino]-4-methylsulfanyl-butyrylamino}-4-methyl-pentanoylamino)-acetic acid
• CAS No.: 98625-49-1
• Molecular Formula: C₄₄H₅₉N₅O₉S₂
• Molecular Weight: 866.113
• Mol file: 98625-49-1.mol

Synonyms:

Chemical Property of (2-{2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-tritylsulfanyl-propionylamino]-4-methylsulfanyl-butyrylamino}-4-methyl-pentanoylamino)-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-{2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-tritylsulfanyl-propionylamino]-4-methylsulfanyl-butyrylamino}-4-methyl-pentanoylamino)-acetic acid

There total 2 articles about (2-{2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-tritylsulfanyl-propionylamino]-4-methylsulfanyl-butyrylamino}-4-methyl-pentanoylamino)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{2-[2-(2-Amino-3-tritylsulfanyl-propionylamino)-4-methylsulfanyl-butyrylamino]-4-methyl-pentanoylamino}-acetic acid; compound with trifluoro-acetic acid (98625-48-0) → (2-{2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-tritylsulfanyl-propionylamino]-4-methylsulfanyl-butyrylamino}-4-methyl-pentanoylamino)-acetic acid (98625-49-1)

Guidance literature:

With triethylamine; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1) dioxane, CH₃CO₂H, room temperature, 20 h, 2) DMF, room temperature, 24 h;

DOI:10.1007/BF00574212

Reference yield:

{2-[2-(2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-4-methylsulfanyl-butyrylamino]-4-methyl-pentanoylamino}-acetic acid (98625-47-9) → (2-{2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-tritylsulfanyl-propionylamino]-4-methylsulfanyl-butyrylamino}-4-methyl-pentanoylamino)-acetic acid (98625-49-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 97.7 percent / 1 h / Ambient temperature

2: 1) 1,3-dicyclohexylcarbodiimide, 2) (C₂H₅)3N / 1) dioxane, CH₃CO₂H, room temperature, 20 h, 2) DMF, room temperature, 24 h

With triethylamine; dicyclohexyl-carbodiimide;

DOI:10.1007/BF00574212

Reference yield: 93.5%

(2-{2-[2-(2-tert-Butoxycarbonylamino-3-hydroxy-butyrylamino)-3-tritylsulfanyl-propionylamino]-4-methylsulfanyl-butyrylamino}-4-methyl-pentanoylamino)-acetic acid (98625-49-1) + trifluoroacetic acid (76-05-1) → (2-{2-[2-((2R,3S)-2-Amino-3-hydroxy-butyrylamino)-3-tritylsulfanyl-propionylamino]-4-methylsulfanyl-butyrylamino}-4-methyl-pentanoylamino)-acetic acid; compound with trifluoro-acetic acid (98625-51-5)

Guidance literature:

for 1h; Ambient temperature;

DOI:10.1007/BF00574212

upstream raw materials:

{2-[2-(2-Amino-3-tritylsulfanyl-propionylamino)-4-methylsulfanyl-butyrylamino]-4-methyl-pentanoylamino}-acetic acid; compound with trifluoro-acetic acid

{2-[2-(2-tert-Butoxycarbonylamino-3-tritylsulfanyl-propionylamino)-4-methylsulfanyl-butyrylamino]-4-methyl-pentanoylamino}-acetic acid

Downstream raw materials:

(2-{2-[2-((2R,3S)-2-Amino-3-hydroxy-butyrylamino)-3-tritylsulfanyl-propionylamino]-4-methylsulfanyl-butyrylamino}-4-methyl-pentanoylamino)-acetic acid; compound with trifluoro-acetic acid