3-Oxazolidinecarboxylic acid, 2,2-dimethyl-4-(phenylmethyl)-5-[2-(phenylmethyl)-2-propenyl]-, 1,1-dimethylethyl ester, (4S,5S)-

Base Information

Chemical Name:3-Oxazolidinecarboxylic acid, 2,2-dimethyl-4-(phenylmethyl)-5-[2-(phenylmethyl)-2-propenyl]-, 1,1-dimethylethyl ester, (4S,5S)-
CAS No.:143006-60-4
Molecular Formula:C27H35NO3
Molecular Weight:421.58
Hs Code.:
Mol file:143006-60-4.mol

Synonyms:

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Chemical Property of 3-Oxazolidinecarboxylic acid, 2,2-dimethyl-4-(phenylmethyl)-5-[2-(phenylmethyl)-2-propenyl]-, 1,1-dimethylethyl ester, (4S,5S)-

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 3-Oxazolidinecarboxylic acid, 2,2-dimethyl-4-(phenylmethyl)-5-[2-(phenylmethyl)-2-propenyl]-, 1,1-dimethylethyl ester, (4S,5S)-

There total 7 articles about 3-Oxazolidinecarboxylic acid, 2,2-dimethyl-4-(phenylmethyl)-5-[2-(phenylmethyl)-2-propenyl]-, 1,1-dimethylethyl ester, (4S,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 77-76-9
2,2-dimethoxy-propane

: (4S)-2-benzyl-5-[(tert-butoxycarbonyl)amino]-6-phenylhex-1-en-4-ol

: 143006-60-4
(4S,5S)-4-benzyl-5-(2-benzyl-3-propenyl)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidine

Guidance literature:: With toluene-4-sulfonic acid; at 25 ℃;
DOI:10.1055/s-2002-34891

Reference yield:

: 143006-54-6
(4S,5S)-5-((tert-butoxycarbonyl)amino)-2-(chloromethyl)-6-phenyl-1-hexen-4-ol

: 143006-60-4
(4S,5S)-4-benzyl-5-(2-benzyl-3-propenyl)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / p-TsOH / 46 h / Ambient temperature

2: NaI / acetone / 12 h

3: 1) CuCN / 1) THF, cyclohexane, a) 30 min, -23 deg C, b) 30 min, 0 deg C, 2) THF, rt, 1 h

With toluene-4-sulfonic acid; sodium iodide; In acetone;
DOI:10.1021/jo00045a045

Reference yield:

: 143006-56-8
(4S,5S)-4-benzyl-3-(tert-butoxycarbonyl)-5-(2-(chloromethyl)-3-propenyl)-2,2-dimethyl-1,3-oxazolidine

: 143006-60-4
(4S,5S)-4-benzyl-5-(2-benzyl-3-propenyl)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: NaI / acetone / 12 h

2: 1) CuCN / 1) THF, cyclohexane, a) 30 min, -23 deg C, b) 30 min, 0 deg C, 2) THF, rt, 1 h

With sodium iodide; In acetone;
DOI:10.1021/jo00045a045