1,3-Propanediamine, 2,2-bis(aminomethyl)-, tetrahydrochloride

Base Information

• Chemical Name: 1,3-Propanediamine, 2,2-bis(aminomethyl)-, tetrahydrochloride
• CAS No.: 14302-75-1
• Molecular Formula: C5H16N4.4ClH
• Molecular Weight: 278.053
• Mol file: 14302-75-1.mol

Synonyms:

Chemical Property of 1,3-Propanediamine, 2,2-bis(aminomethyl)-, tetrahydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Propanediamine, 2,2-bis(aminomethyl)-, tetrahydrochloride

There total 3 articles about 1,3-Propanediamine, 2,2-bis(aminomethyl)-, tetrahydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-diazido-2,2-bis(azidomethyl)propane (31107-13-8) → 2,2-bis(aminomethyl)propane-1,3-diamine tetrahydrochloride (14302-75-1)

Guidance literature:

1,3-diazido-2,2-bis(azidomethyl)propane; With pyridine; triphenylphosphine; at 0 ℃;

With ammonia; In water;

With hydrogenchloride; In ethanol; at 0 ℃;

DOI:10.1016/j.inoche.2010.06.018

Reference yield:

Pentaerythritol (115-77-5) → 2,2-bis(aminomethyl)propane-1,3-diamine tetrahydrochloride (14302-75-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide

2.1: sodium azide / dimethyl sulfoxide / 48 h / 70 °C / Inert atmosphere

3.1: pyridine; triphenylphosphine / 0 °C

3.3: 0 °C

With pyridine; sodium azide; triphenylphosphine; sodium hydroxide; In dimethyl sulfoxide;

DOI:10.1016/j.inoche.2010.06.018

Reference yield:

pentaerythritol tetrakis(benzenesulfonate) (2514-70-7) → 2,2-bis(aminomethyl)propane-1,3-diamine tetrahydrochloride (14302-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium azide / dimethyl sulfoxide / 48 h / 70 °C / Inert atmosphere

2.1: pyridine; triphenylphosphine / 0 °C

2.3: 0 °C

With pyridine; sodium azide; triphenylphosphine; In dimethyl sulfoxide;

DOI:10.1016/j.inoche.2010.06.018

upstream raw materials:

Pentaerythritol

1,3-diazido-2,2-bis(azidomethyl)propane

pentaerythritol tetrakis(benzenesulfonate)

Downstream raw materials:

2,6-diazaspiro[3.3]heptane

C,C'-azetidine-3,3-diyl-bis-methylamine

1,1,1,1-tetrakis[(2-salicylaldimino)methyl]methane