Tetrakis(salicylideneaminoethyl)methane

Base Information

• Chemical Name: Tetrakis(salicylideneaminoethyl)methane
• CAS No.: 3221-64-5
• Molecular Formula: C33H32 N4 O4
• Molecular Weight: 548.641
• European Community (EC) Number: 221-749-1
• DSSTox Substance ID: DTXSID6062913
• Nikkaji Number: J262.328E
• Mol file: 3221-64-5.mol

Synonyms:Tetrakis(salicylideneaminoethyl)methane;3221-64-5;EINECS 221-749-1;Phenol, 2,2'-[[2,2-bis[[[(2-hydroxyphenyl)methylene]amino]methyl]-1,3-propanediyl]bis(nitrilomethylidyne)]bis-;2,2'-[[2,2-bis[[[(2-hydroxyphenyl)methylene]amino]methyl]propane-1,3-diyl]bis(nitrilomethylidyne)]bisphenol;Phenol, 2,2'-((2,2-bis((((2-hydroxyphenyl)methylene)amino)methyl)-1,3-propanediyl)bis(nitrilomethylidyne))bis-;2,2'-((2,2-Bis((((2-hydroxyphenyl)methylene)amino)methyl)propane-1,3-diyl)bis(nitrilomethylidyne))bisphenol;DTXSID6062913;SCHEMBL11577369;C33-H32-N4-O4;Tetrakis(salicylideneaminomethyl)methane

Chemical Property of Tetrakis(salicylideneaminoethyl)methane

Chemical Property:

• Boiling Point: 856.1°Cat760mmHg
• Flash Point: 235.1°C
• PSA: 116.40000
• Density: 1.395g/cm³
• LogP: 4.21080
• XLogP3: 4
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 12
• Exact Mass: 548.24235551
• Heavy Atom Count: 41
• Complexity: 736

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C=NCC(CN=CC2=CC=CC=C2O)(CN=CC3=CC=CC=C3O)CN=CC4=CC=CC=C4O)O

Technology Process of Tetrakis(salicylideneaminoethyl)methane

There total 8 articles about Tetrakis(salicylideneaminoethyl)methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,2-bis(aminomethyl)propane-1,3-diamine tetrahydrochloride (14302-75-1) + salicylaldehyde (90-02-8) → 1,1,1,1-tetrakis[(2-salicylaldimino)methyl]methane (3221-64-5)

Guidance literature:

With triethylamine; In methanol;

DOI:10.1016/j.inoche.2010.06.018

Reference yield:

Pentaerythritol (115-77-5) → 1,1,1,1-tetrakis[(2-salicylaldimino)methyl]methane (3221-64-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide

2.1: sodium azide / dimethyl sulfoxide / 48 h / 70 °C / Inert atmosphere

3.1: pyridine; triphenylphosphine / 0 °C

3.3: 0 °C

4.1: triethylamine / methanol

With pyridine; sodium azide; triethylamine; triphenylphosphine; sodium hydroxide; In methanol; dimethyl sulfoxide;

DOI:10.1016/j.inoche.2010.06.018

Reference yield:

1,3-diazido-2,2-bis(azidomethyl)propane (31107-13-8) → 1,1,1,1-tetrakis[(2-salicylaldimino)methyl]methane (3221-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine; triphenylphosphine / 0 °C

1.3: 0 °C

2.1: triethylamine / methanol

With pyridine; triethylamine; triphenylphosphine; In methanol;

DOI:10.1016/j.inoche.2010.06.018

upstream raw materials:

tetrakis(aminomethyl)methane

salicylaldehyde

Pentaerythritol

1,3-diazido-2,2-bis(azidomethyl)propane