benzyl(methyl)(oxiran-2-ylmethyl)amine

Base Information

• Chemical Name: benzyl(methyl)(oxiran-2-ylmethyl)amine
• CAS No.: 14321-26-7
• Molecular Formula: C11H15NO
• Molecular Weight: 177.246
• Mol file: 14321-26-7.mol

Synonyms:Benzyl-methyl-oxiranylmethyl-amin;benzyl-methyl-oxiranylmethyl-amine;N-benzyl-N-methyl-1-oxiran-2-ylmethanamine;

Chemical Property of benzyl(methyl)(oxiran-2-ylmethyl)amine

Chemical Property:

• PSA: 15.77000
• LogP: 1.51720

Purity/Quality:

NLT 98% ^*data from raw suppliers

benzyl(methyl)(oxiran-2-ylmethyl)amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyl(methyl)(oxiran-2-ylmethyl)amine

There total 3 articles about benzyl(methyl)(oxiran-2-ylmethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

benzyl-methyl-amine (103-67-3) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → N-benzyl-N-methyl-1-(oxiran-2-yl)methanamine (14321-26-7)

Guidance literature:

benzyl-methyl-amine; epichlorohydrin; In methanol; at 80 ℃; for 6h;

With potassium hydroxide; In water; tert-butyl alcohol; at 80 ℃; for 2h;

Reference yield: 68.0%

benzyl-methyl-amine (103-67-3) + 1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → N-benzyl-N-methyl-1-(oxiran-2-yl)methanamine (14321-26-7)

Guidance literature:

benzyl-methyl-amine; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

1,2-Epoxy-3-bromopropane; In tetrahydrofuran; Further stages.; Heating;

DOI:10.1021/jm070553l

Reference yield:

→ N-benzyl-N-methyl-1-(oxiran-2-yl)methanamine (14321-26-7)

Guidance literature:

Benzylmethylamin, Epichlorhydrin;

DOI:10.1002/hlca.19770600523

upstream raw materials:

benzyl-methyl-amine

epichlorohydrin

1,2-Epoxy-3-bromopropane

Downstream raw materials:

2-amino-5-(N-benzyl-N-methylaminomethyl)-2-oxazoline

1-(Benzyl-methyl-amino)-3-(3,3,4,4,5,5,6,6,6-nonafluoro-hexylamino)-propan-2-ol

1,3-bis-(benzyl-methyl-amino)-propan-2-ol

(+/-)-1-[N-benzyl-N-methylamino]-3-[3-thieno[2,3-d]isoxazol-3-yl-phenoxy]-2-propanol

Refernces

• 1、 Robin, Aélig,Brown, Fraser,Bahamontes-Rosa, Noemí,Wu, Binghua,Beitz, Eric,Kun, Jürgen F. J.,Flitsch, Sabine L.. "Microwave-assisted ring opening of epoxides: A general route to the synthesis of 1-aminopropan-2-ols with anti malaria parasite activities". . p. 4243 - 4249. Retrieved 2008/02/12.
• 2、 -. "Trimeric macrocyclic substituted benzene derivatives". Page/Page column 14. . Retrieved 2010/02/10.