Tamoxifen hydrochloride

Base Information

Chemical Name:Tamoxifen hydrochloride
CAS No.:66584-35-8
Molecular Formula:C₂₆H₂₉NO*ClH
Molecular Weight:407.983
Hs Code.:
UNII:X545Q5UB3E

Synonyms:tamoxifen hydrochloride;X545Q5UB3E;UNII-X545Q5UB3E;66584-35-8;Ethanamine, 2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-, hydrochloride, (Z)-;SCHEMBL3794383

Suppliers and Price of Tamoxifen hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of Tamoxifen hydrochloride

Chemical Property:

Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:8
Exact Mass:407.2015923
Heavy Atom Count:29
Complexity:463

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3.Cl
Isomeric SMILES:CC/C(=C(\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3.Cl

Technology Process of Tamoxifen hydrochloride

There total 2 articles about Tamoxifen hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 622-76-4,83585-27-7
1-phenyl-1-butyne

: 66584-35-8
tamoxifen hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Ni(acac)2, NMP, 2.) I₂ / 1.) THF, -35 deg C, 3 h, 2.) THF, -78 deg C -> -10 deg C; -10 deg C, 5 min

With 1-methyl-pyrrolidin-2-one; bis(acetylacetonate)nickel(II); iodine;
DOI:10.1016/S0040-4020(97)10226-5