Ethanamine, 2-(4-iodophenoxy)-N,N-dimethyl-

Base Information

• Chemical Name: Ethanamine, 2-(4-iodophenoxy)-N,N-dimethyl-
• CAS No.: 93790-54-6
• Molecular Formula: C10H14INO
• Molecular Weight: 291.132
• DSSTox Substance ID: DTXSID30358324
• Nikkaji Number: J1.928.493J
• Wikidata: Q82138812
• Mol file: 93790-54-6.mol

Synonyms:93790-54-6;Ethanamine, 2-(4-iodophenoxy)-N,N-dimethyl-;2-(4-iodophenoxy)-N,N-dimethylethanamine;[2- (4- iodophenoxy) ethyl] dimethylamine;C10H14INO;SCHEMBL2645547;DTXSID30358324;NPBOBLCVKKOINL-UHFFFAOYSA-N;[2-(4-iodophenoxy)ethyl]dimethylamine;AKOS008968380

Chemical Property of Ethanamine, 2-(4-iodophenoxy)-N,N-dimethyl-

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 291.01201
• Heavy Atom Count: 13
• Complexity: 133

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCOC1=CC=C(C=C1)I

Technology Process of Ethanamine, 2-(4-iodophenoxy)-N,N-dimethyl-

There total 5 articles about Ethanamine, 2-(4-iodophenoxy)-N,N-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-Iodophenol (540-38-5) + 2-(dimethylamino)ethyl chloride (107-99-3) → [2-(4-iodophenoxy)ethyl]dimethylamine (93790-54-6)

Guidance literature:

With potassium carbonate; In acetone; for 8h; Reflux;

DOI:10.1039/c4ob00220b

Reference yield: 93.0%

p-Iodophenol (540-38-5) + (2-chloroethyl)dimethylamine hydrochloride (4584-46-7) → [2-(4-iodophenoxy)ethyl]dimethylamine (93790-54-6)

Guidance literature:

With potassium carbonate; In acetone; Reflux;

Reference yield:

4-<2-(dimethylamino)ethoxy>aniline (62345-76-0) → [2-(4-iodophenoxy)ethyl]dimethylamine (93790-54-6)

Guidance literature:

With sodium [¹²⁷I]iodide; sulfuric acid; urea; sodium sulfite; sodium nitrite; Yield given. Multistep reaction; 1.) 0 deg C, 10 min, water; 2.) 10 min, 0 deg C, water; 3.) 10 min, r.t.; 4.) 6 min, 80 deg C;

DOI:10.1139/v84-344

upstream raw materials:

p-Iodophenol

(2-chloroethyl)dimethylamine hydrochloride

4-<2-(dimethylamino)ethoxy>aniline

2-(dimethylamino)ethyl chloride

Downstream raw materials:

tamoxifen hydrochloride

Dimethyl-[2-(4-phenylethynyl-phenoxy)-ethyl]-amine

(E)-N,N-dimethyl-2-(4-(1-phenyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-1-en-1-yl)phenoxy)ethanamine

tamoxifen