ethyl (1R,2R)-2-aminocyclohexane-1-carboxylate

Base Information

Chemical Name:ethyl (1R,2R)-2-aminocyclohexane-1-carboxylate
CAS No.:1436-61-9
Molecular Formula:C₉H₁₇NO₂
Molecular Weight:171.239
Hs Code.:
DSSTox Substance ID:DTXSID801245110
Nikkaji Number:J2.506.559J
Mol file:1436-61-9.mol

Synonyms:ethyl (1R,2R)-2-aminocyclohexane-1-carboxylate;1436-61-9;1436-60-8;TRANS-2-AMINO-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER;(1R,2R)-2-AMINO-CYCLOHEXANECARBOXYLIC ACID ETHYL ESTER;26849-62-7;Cyclohexanecarboxylicacid, 2-amino-, ethyl ester, (1R,2S)-rel-;(1R,2R)-Ethyl 2-aminocyclohexanecarboxylate;cis-2-Amino-cyclohexanecarboxylic acid ethyl ester;SCHEMBL196;DTXSID801245110;AMY14674;MFCD00154531;AKOS006281191;trans-Ethyl 2-aminocyclohexanecarboxylate;(1R*,2R*)-ethyl 2-aminocyclohexanecarboxylate;EN300-1590561;rel-Ethyl (1R,2R)-2-aminocyclohexanecarboxylate;(trans)-2-amino-cyclohexanecarboxylic acid ethyl ester;(1R,2R)-2-AMINO-CYCLOHEXANECARBOXYLICACIDETHYLESTER;(1R,2R)-2-Aminocyclohexane-1-carboxylic acid ethyl ester

Suppliers and Price of ethyl (1R,2R)-2-aminocyclohexane-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of ethyl (1R,2R)-2-aminocyclohexane-1-carboxylate

Chemical Property:

PSA：52.32000
LogP:1.76730
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:171.125928785
Heavy Atom Count:12
Complexity:159

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1CCCCC1N
Isomeric SMILES:CCOC(=O)[C@@H]1CCCC[C@H]1N

Technology Process of ethyl (1R,2R)-2-aminocyclohexane-1-carboxylate

There total 5 articles about ethyl (1R,2R)-2-aminocyclohexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1469-49-4,2028-12-8
6-carbamoylcyclohex-3-enecarboxylic acid

: 1436-60-8,1436-61-9,24716-94-7,26849-62-7,64162-07-8,75197-07-8,115014-75-0
ethyl cis-2-amino-1-cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / H₂ / 10percent Pt/C / ethanol / 760 Torr / Ambient temperature

2: 1.) bromine, NaOH; 2.) HCl / 1.) water, 75 deg C, 2 min; 2.) reflux, 3 h

With hydrogenchloride; sodium hydroxide; hydrogen; bromine; platinum on activated charcoal; In ethanol;
DOI:10.1016/S0040-4020(01)85926-3

Reference yield:

: 1128-00-3
ethyl 2-aminocyclohex-1-ene-1-carboxylate

: 1436-60-8,1436-61-9,24716-94-7,26849-62-7,64162-07-8,75197-07-8,115014-75-0
ethyl cis-2-amino-1-cyclohexanecarboxylate

Guidance literature:: With sodium cyanoborohydride; acetic acid; In ethyl acetate; at 0 ℃; for 6h;
DOI:10.1002/adsc.201300982

Reference yield:

: 1655-07-8
ethyl 2-oxocyclohexane carboxylate

: 1436-60-8,1436-61-9,24716-94-7,26849-62-7,64162-07-8,75197-07-8,115014-75-0
ethyl cis-2-amino-1-cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / methanol / 48 h / 20 °C

2: sodium cyanoborohydride; acetic acid / ethyl acetate / 6 h / 0 °C

With ammonium acetate; sodium cyanoborohydride; acetic acid; In methanol; ethyl acetate;
DOI:10.1002/adsc.201300982