N-[2-[4-(Acetyloxy)phenyl]ethyl]acetamide

Base Information

• Chemical Name: N-[2-[4-(Acetyloxy)phenyl]ethyl]acetamide
• CAS No.: 14383-56-3
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.256
• Hs Code.: 2924299090
• Mol file: 14383-56-3.mol

Synonyms:HMS555E16;tyramine N,O-diacetate;O.N-Diacetyl-tyramin;tyramine-diacetate;

Chemical Property of N-[2-[4-(Acetyloxy)phenyl]ethyl]acetamide

Chemical Property:

• PSA: 58.89000
• LogP: 2.13080

Purity/Quality:

N,O-Diacetyltyramine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[2-[4-(Acetyloxy)phenyl]ethyl]acetamide

There total 10 articles about N-[2-[4-(Acetyloxy)phenyl]ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

tyrosamine (51-67-2) + acetic anhydride (108-24-7) + acetic acid (64-19-7,77671-22-8) → 4-[2-(acetylamino)ethyl]phenyl acetate (14383-56-3)

Guidance literature:

for 2h; Reflux;

DOI:10.1007/s11164-014-1630-9

Reference yield: 23.0%

tyrosamine (51-67-2) + acetyl chloride (75-36-5) → N-acetyltyramine (1202-66-0) + 4-[2-(acetylamino)ethyl]phenyl acetate (14383-56-3) + 4-(2-aminoethyl)-phenyl acetate (20284-85-9)

Guidance literature:

tyrosamine; With sodium hydride; In dichloromethane; for 0.25h; Inert atmosphere;

acetyl chloride; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.tet.2008.12.052

Reference yield: 11.0%

tyrosamine (51-67-2) → 4-[2-(acetylamino)ethyl]phenyl acetate (14383-56-3)

Guidance literature:

With sodium hydroxide; In chloroform; water; for 1h; Ambient temperature;

DOI:10.1246/bcsj.61.247

upstream raw materials:

tyrosamine

acetic anhydride

N-acetyltyramine

acetyl chloride

Downstream raw materials:

N-acetyltyramine

Refernces

• 1、 Quevedo, Rodolfo,Nu?ez-Dallos, Nelson,Qui?ones, Martha L.. "Larvicidal activity of single and macrocyclic tyrosine derivatives against three important vector mosquitoes". . p. 5283 - 5292. Retrieved 2015.
• 2、 Kumar, Vishal,Singh, Chitra,Sharma, Upendra,Verma, Praveen K.,Singh, Bikram,Kumar, Neeraj. "Silica-supported boric acid catalyzed synthesis of dihydropyrimidin-2-ones, bis(indolyl)methanes, esters and amides". . p. 83 - 89. Retrieved 2014/02/14.