(5-bromo-2-hydroxy-benzylidene)-malonic acid

Base Information

• Chemical Name: (5-bromo-2-hydroxy-benzylidene)-malonic acid
• CAS No.: 854847-10-2
• Molecular Formula: C₁₀H₇BrO₅
• Molecular Weight: 287.067
• Mol file: 854847-10-2.mol

Synonyms:

Chemical Property of (5-bromo-2-hydroxy-benzylidene)-malonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5-bromo-2-hydroxy-benzylidene)-malonic acid

There total 3 articles about (5-bromo-2-hydroxy-benzylidene)-malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

malonic acid (141-82-2) + 5-bromosalicyclaldehyde (1761-61-1) → (E)-3-(5-bromo-2-hydroxyphenyl)acrylic acid (60410-95-9) + (5-bromo-2-hydroxy-benzylidene)-malonic acid (854847-10-2)

Guidance literature:

With pyridine; at 105 ℃;

Reference yield:

salicylaldehyde (90-02-8) → (5-bromo-2-hydroxy-benzylidene)-malonic acid (854847-10-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; bromine

2: pyridine / 105 °C

With pyridine; bromine; acetic acid;

Reference yield:

pyridine (110-86-1) + malonic acid (141-82-2) + 5-bromosalicyclaldehyde (1761-61-1) → (E)-3-(5-bromo-2-hydroxyphenyl)acrylic acid (60410-95-9) + (5-bromo-2-hydroxy-benzylidene)-malonic acid (854847-10-2)

Guidance literature:

at 100 ℃;

upstream raw materials:

pyridine

malonic acid

5-bromosalicyclaldehyde

salicylaldehyde

Downstream raw materials:

(E)-3-(5-bromo-2-hydroxyphenyl)acrylic acid