E-2-(2-phenyl propen-1-yl) 3-nitroimidazo<1,2-a>pyridine

Base Information

• Chemical Name: E-2-(2-phenyl propen-1-yl) 3-nitroimidazo<1,2-a>pyridine
• CAS No.: 135921-62-9
• Molecular Formula: C₁₆H₁₃N₃O₂
• Molecular Weight: 279.298
• Mol file: 135921-62-9.mol

Synonyms:

Chemical Property of E-2-(2-phenyl propen-1-yl) 3-nitroimidazo<1,2-a>pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of E-2-(2-phenyl propen-1-yl) 3-nitroimidazo<1,2-a>pyridine

There total 3 articles about E-2-(2-phenyl propen-1-yl) 3-nitroimidazo<1,2-a>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloromethylimidazo[1,2-a]pyridine (57892-76-9) → E-2-(2-phenyl propen-1-yl) 3-nitroimidazo<1,2-a>pyridine (135921-62-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / conc. H₂SO₄, HNO₃ (d=1.38) / 2 h / 20 °C

With sulfuric acid; nitric acid;

DOI:10.1016/S0040-4020(01)87129-5

Reference yield:

2-(chloromethyl)-3-nitro-1H-imdiazo[1,2-a]pyridine (129179-30-2) + (1-nitroethyl)benzene (7214-61-1) → E-2-(2-phenyl propen-1-yl) 3-nitroimidazo<1,2-a>pyridine (135921-62-9)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1016/S0040-4020(01)87129-5

Reference yield:

2-aminopyridine (504-29-0) → E-2-(2-phenyl propen-1-yl) 3-nitroimidazo<1,2-a>pyridine (135921-62-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / 1,2-dimethoxy-ethane / 2 h / 20 °C

2: 76 percent / conc. H₂SO₄, HNO₃ (d=1.38) / 2 h / 20 °C

With sulfuric acid; nitric acid; In 1,2-dimethoxyethane;

DOI:10.1016/S0040-4020(01)87129-5

upstream raw materials:

2-(chloromethyl)-3-nitro-1H-imdiazo[1,2-a]pyridine

(1-nitroethyl)benzene

2-aminopyridine

2-chloromethylimidazo[1,2-a]pyridine