Benzyl [1-(4-methoxyphenyl)ethyl]amine

Base Information

• Chemical Name: Benzyl [1-(4-methoxyphenyl)ethyl]amine
• CAS No.: 14429-03-9
• Molecular Formula: C16H19NO
• Molecular Weight: 241.333
• DSSTox Substance ID: DTXSID201212060
• Nikkaji Number: J2.189.200I
• Mol file: 14429-03-9.mol

Synonyms:SCHEMBL23992068;DTXSID201212060;AKOS000225790;benzyl [1-(4-methoxyphenyl)ethyl]amine;N-Benzyl-1-(4-methoxyphenyl)ethaneamine;N-benzyl-1-(4-methoxyphenyl)ethan-1-amine;4-Methoxy-alpha-methyl-N-(phenylmethyl)benzenemethanamine;14429-03-9

Chemical Property of Benzyl [1-(4-methoxyphenyl)ethyl]amine

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 241.146664230
• Heavy Atom Count: 18
• Complexity: 217

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=C(C=C1)OC)NCC2=CC=CC=C2

Technology Process of Benzyl [1-(4-methoxyphenyl)ethyl]amine

There total 24 articles about Benzyl [1-(4-methoxyphenyl)ethyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1(R)-(4-methoxyphenyl)-ethylamine (6298-96-0,22038-86-4,35600-82-9,41851-59-6) + benzaldehyde (100-52-7) → (R)-N-benzyl-N-(α-methyl-p-methoxybenzyl)amine (14429-03-9,120343-46-6,140408-66-8)

Guidance literature:

1(R)-(4-methoxyphenyl)-ethylamine; benzaldehyde; With 4 Angstroem MS; In methanol; at 20 ℃; for 4h;

With sodium tetrahydroborate; In methanol;

DOI:10.1016/S0040-4039(03)00570-7

Reference yield: 96.0%

N-(α-methyl-4-methoxybenzylidene)benzylamine (14429-17-5) → N-benzyl-N-(α-methyl-p-methoxybenzyl)amine (14429-03-9)

Guidance literature:

With iron(III)-acetylacetonate; [2,5-(SiMe3)2-3,4-(CH2)4(η5-C4CO)Fe(CO)2(PhCN); isopropyl alcohol; at 110 ℃; for 48h; Inert atmosphere; Sealed tube;

DOI:10.1039/c5ob02119g

Reference yield: 96.0%

anti-N-(α-methyl-4-methoxybenzylidene)benzylamine (14429-17-5) → (S)-N-benzyl-N-(α-methyl-p-methoxybenzyl)amine (120343-46-6) + (R)-N-benzyl-N-(α-methyl-p-methoxybenzyl)amine (14429-03-9,120343-46-6,140408-66-8)

Guidance literature:

With rhodium(I)-sulfonated-(-)-(2S,4S)-2,4-bis(diphenylphosphino)pentane; hydrogen; In water; ethyl acetate; at 20 ℃; for 6h; under 52504.2 Torr; Title compound not separated from byproducts;

DOI:10.1039/c39910001684

upstream raw materials:

N-(α-methyl-4-methoxybenzylidene)benzylamine

anti-N-(α-methyl-4-methoxybenzylidene)benzylamine

chloro-benzyl amine

1(R)-(4-methoxyphenyl)-ethylamine

Downstream raw materials:

tert-butyl (R,R)-3-[N-benzyl-N-(α-methyl-p-methoxybenzyl)amino]-4-(2',4',5'-trifluorophenyl)butanoate

(R,R,R)-2-benzyloxy-3-[N-benzyl-N-(α-methyl-4'-methoxybenzyl)amino]butan-1-ol

(R,R,R,R)-N⁽¹⁾-2-(4'-methoxyphenyl)-3,4-diacetoxy-5-methylpyrrolidine

C₁₉H₂₃NO₃