1,3-Benzenediacetic acid, 2-methoxy-

Base Information

• Chemical Name: 1,3-Benzenediacetic acid, 2-methoxy-
• CAS No.: 144316-88-1
• Molecular Formula: C11H12O5
• Molecular Weight: 224.213
• Mol file: 144316-88-1.mol

Synonyms:

Chemical Property of 1,3-Benzenediacetic acid, 2-methoxy-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Benzenediacetic acid, 2-methoxy-

There total 3 articles about 1,3-Benzenediacetic acid, 2-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2,6-bis(cyanomethyl)anisole (144316-87-0) → 2,6-bis(carboxymethyl)anisole (144316-88-1)

Guidance literature:

With sodium hydroxide; Heating;

DOI:10.1021/jo00051a010

Reference yield:

2-methoxy-1,3-dimethylbenzene (1004-66-6) → 2,6-bis(carboxymethyl)anisole (144316-88-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / N,N'-dibromo-5,5-dimethylhydantoin, benzoyl peroxide / CCl₄ / 2 h / Heating; Irradiation

2: 95 percent / hexadecyldimethylethylammonium bromide / benzene; H₂O / 5 h / Heating

3: 91 percent / 7percent aq. NaOH / Heating

With sodium hydroxide; Perbenzoic acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; hexadecyldimethylethylammonium bromide; In tetrachloromethane; water; benzene;

DOI:10.1021/jo00051a010

Reference yield:

2,6-bis(bromomethyl)anisole (30787-74-7) → 2,6-bis(carboxymethyl)anisole (144316-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / hexadecyldimethylethylammonium bromide / benzene; H₂O / 5 h / Heating

2: 91 percent / 7percent aq. NaOH / Heating

With sodium hydroxide; hexadecyldimethylethylammonium bromide; In water; benzene;

DOI:10.1021/jo00051a010

upstream raw materials:

2,6-bis(cyanomethyl)anisole

2-methoxy-1,3-dimethylbenzene

2,6-bis(bromomethyl)anisole

Downstream raw materials:

(3-Ethoxycarbonylmethyl-2-methoxy-phenyl)-acetic acid ethyl ester

(3-Chlorocarbonylmethyl-2-methoxy-phenyl)-acetyl chloride

3-[3-(2-carboxyethyl)-2-methoxyphenyl]propionic acid

2-[3-(2-Hydroxy-ethyl)-2-methoxy-phenyl]-ethanol