1,3-Benzenediacetyl dichloride, 2-methoxy-

Base Information

• Chemical Name: 1,3-Benzenediacetyl dichloride, 2-methoxy-
• CAS No.: 144316-89-2
• Molecular Formula: C11H10Cl2O3
• Molecular Weight: 261.105
• Mol file: 144316-89-2.mol

Synonyms:

Chemical Property of 1,3-Benzenediacetyl dichloride, 2-methoxy-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Benzenediacetyl dichloride, 2-methoxy-

There total 4 articles about 1,3-Benzenediacetyl dichloride, 2-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,6-bis(carboxymethyl)anisole (144316-88-1) → (3-Chlorocarbonylmethyl-2-methoxy-phenyl)-acetyl chloride (144316-89-2)

Guidance literature:

With pyridine; oxalyl dichloride; In benzene; for 48h; Ambient temperature;

DOI:10.1021/jo00051a010

Reference yield:

2-methoxy-1,3-dimethylbenzene (1004-66-6) → (3-Chlorocarbonylmethyl-2-methoxy-phenyl)-acetyl chloride (144316-89-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 72 percent / N,N'-dibromo-5,5-dimethylhydantoin, benzoyl peroxide / CCl₄ / 2 h / Heating; Irradiation

2: 95 percent / hexadecyldimethylethylammonium bromide / benzene; H₂O / 5 h / Heating

3: 91 percent / 7percent aq. NaOH / Heating

4: 98 percent / oxalyl chloride, pyridine / benzene / 48 h / Ambient temperature

With pyridine; sodium hydroxide; Perbenzoic acid; oxalyl dichloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; hexadecyldimethylethylammonium bromide; In tetrachloromethane; water; benzene;

DOI:10.1021/jo00051a010

Reference yield:

2,6-bis(bromomethyl)anisole (30787-74-7) → (3-Chlorocarbonylmethyl-2-methoxy-phenyl)-acetyl chloride (144316-89-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / hexadecyldimethylethylammonium bromide / benzene; H₂O / 5 h / Heating

2: 91 percent / 7percent aq. NaOH / Heating

3: 98 percent / oxalyl chloride, pyridine / benzene / 48 h / Ambient temperature

With pyridine; sodium hydroxide; oxalyl dichloride; hexadecyldimethylethylammonium bromide; In water; benzene;

DOI:10.1021/jo00051a010

upstream raw materials:

2,6-bis(carboxymethyl)anisole

2-methoxy-1,3-dimethylbenzene

2,6-bis(bromomethyl)anisole

2,6-bis(cyanomethyl)anisole

Downstream raw materials:

[17-Methoxy-10-methoxycarbonylmethyl-16-nitro-15-(2,4,6-trinitro-phenylamino)-7-oxa-4,10-diaza-bicyclo[11.3.1]heptadeca-1⁽¹⁶⁾,13⁽¹⁷⁾,14-trien-4-yl]-acetic acid methyl ester

[17-Methoxy-10-methoxycarbonylmethyl-15-(2,4,6-trinitro-phenylamino)-7-oxa-4,10-diaza-bicyclo[11.3.1]heptadeca-1⁽¹⁶⁾,13⁽¹⁷⁾,14-trien-4-yl]-acetic acid methyl ester