Propanoic acid, 2-[(4-methoxyphenyl)methoxy]-, ethyl ester, (2S)-

Base Information

• Chemical Name: Propanoic acid, 2-[(4-methoxyphenyl)methoxy]-, ethyl ester, (2S)-
• CAS No.: 144401-98-9
• Molecular Formula: C13H18O4
• Molecular Weight: 238.284
• Mol file: 144401-98-9.mol

Synonyms:(S)-2-(4-Methoxy-benzyloxy)-propionic acid ethyl ester;(2S) ethyl 2-(p-methoxybenzyloxy)propanoate;ethyl (S)-2-(4-methoxybenzyloxy)propanoate;ethyl (S)-2-(p-methoxybenzyloxy)propanoate;ethyl O-(4-methoxybenzyl)-(S)-lactate;ethyl (S)-2-O-(4'-methoxybenzyl)lactate;(S)-ethyl 2-((4-methoxybenzyl)oxy)propanoate;

Chemical Property of Propanoic acid, 2-[(4-methoxyphenyl)methoxy]-, ethyl ester, (2S)-

Chemical Property:

• PSA: 44.76000
• LogP: 2.16340

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanoic acid, 2-[(4-methoxyphenyl)methoxy]-, ethyl ester, (2S)-

There total 7 articles about Propanoic acid, 2-[(4-methoxyphenyl)methoxy]-, ethyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-Ethyl lactate (687-47-8) + 2-[(4-methoxybenzyl)oxy]-3-nitropyridine (350848-02-1) → (S)-2-(4-methoxybenzyloxy)propionic acid ethyl ester (144401-98-9)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1246/cl.2001.424

Reference yield: 97.0%

(S)-Ethyl lactate (687-47-8) + O-(4-methoxybenzyl)-trichloroacetimidate (89238-99-3) → (S)-2-(4-methoxybenzyloxy)propionic acid ethyl ester (144401-98-9)

Guidance literature:

With camphor-10-sulfonic acid; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1002/anie.200703930

Reference yield: 93.0%

(S)-Ethyl lactate (687-47-8) + p-methoxybenzyl chloride (824-94-2) → (S)-2-(4-methoxybenzyloxy)propionic acid ethyl ester (144401-98-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; sodium iodide; at 150 ℃; for 1h; Inert atmosphere; Neat (no solvent);

DOI:10.1016/j.tet.2011.10.016

upstream raw materials:

(S)-Ethyl lactate

p-methoxybenzyl chloride

O-(4-methoxybenzyl)-trichloroacetimidate

2-[(4-methoxybenzyl)oxy]-3-nitropyridine

Downstream raw materials:

2-p-methoxybenzyloxypropionic acid

(S)-(p-methoxybenzyloxy)propanal

(4S) tert-butyl 4-(p-methoxybenzyloxy)-3-oxopentanoate

(3S)-1-bromo-3-(p-methoxybenzyloxy)butan-2-one