2-p-methoxybenzyloxypropionic acid

Base Information

• Chemical Name: 2-p-methoxybenzyloxypropionic acid
• CAS No.: 144068-33-7
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.23
• Mol file: 144068-33-7.mol

Synonyms:2-p-methoxybenzyloxypropionic acid

Chemical Property of 2-p-methoxybenzyloxypropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-p-methoxybenzyloxypropionic acid

There total 4 articles about 2-p-methoxybenzyloxypropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

methyl 2-(4-methoxybenzyloxy)propionate (865620-61-7) → 2-p-methoxybenzyloxypropionic acid (144068-33-7)

Guidance literature:

methyl 2-(4-methoxybenzyloxy)propionate; With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 38h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=1;

Reference yield:

2-(4-Methoxy-benzyloxy)-propionic acid ethyl ester (144401-98-9) → 2-p-methoxybenzyloxypropionic acid (144068-33-7)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1039/c39920001229

Reference yield:

p-methoxybenzyl chloride (824-94-2) → 2-p-methoxybenzyloxypropionic acid (144068-33-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Ag₂O / diethyl ether

2: NaOH / methanol

With sodium hydroxide; silver(l) oxide; In methanol; diethyl ether;

DOI:10.1039/c39920001229

upstream raw materials:

2-(4-Methoxy-benzyloxy)-propionic acid ethyl ester

p-methoxybenzyl chloride

methyl 2-(4-methoxybenzyloxy)propionate

Downstream raw materials:

2-(4-Methoxy-benzyloxy)-propionic acid (S)-1-{(S)-1-[(1R,3aR,4S,7aR)-4-(tert-butyl-dimethyl-silanyloxy)-7a-methyl-octahydro-inden-1-yl]-ethyl}-allyl ester

5-[2-(4-methoxy-benzyloxy)-propionylamino]-4-oxo-pentanoic acid methyl ester