Fonsartan free acid

Base Information

Chemical Name:Fonsartan free acid
CAS No.:144628-52-4
Molecular Formula:C26H32N4O5S2
Molecular Weight:544.696
Hs Code.:
UNII:8DA56TKF53
Nikkaji Number:J686.807J
ChEMBL ID:CHEMBL76525
Mol file:144628-52-4.mol

Synonyms:Fonsartan free acid;HR-720 free acid;144628-52-4;8DA56TKF53;UNII-8DA56TKF53;CHEMBL76525;1H-Imidazole-5-carboxylic acid, 2-butyl-4-(methylthio)-1-((2'-((((propylamino)carbonyl)amino)sulfonyl)(1,1'-biphenyl)-4-yl)methyl)-;2-Butyl-4-(methylsulfanyl)-1-((2'-(((propylcarbamoyl)amino)sulfonyl)-(1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-carboxylic acid;2-butyl-4-(methylthio)-1-((2'-(N-(propylcarbamoyl)sulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylic acid;FONSARTAN POTASSIUM;SCHEMBL7701057;BDBM50031537;AKOS040748372;5-carboxyl imidazolyl biphenyl sulfonylurea derivative;1-[[2'-(3-Propylureidosulfonyl)biphenyl-4-yl]methyl]-2-butyl-4-(methylthio)-1H-imidazole-5-carboxylic acid;2-butyl-1-[[2''-[[[(propylamino)carbonyl]amino]sulfonyl]-(1,1''-biphenyl)-4yl]methyl]-4-(methylthio)-1H-imidazole-5-carboxylic acid;2-Butyl-3-(N''-propylureidylsulfonyl-biphenyl-4-ylmethyl)-5-methylsulfanyl-3H-imidazole-4-carboxylic acid(HR720);2-butyl-5-methylsulfanyl-3-[[4-[2-(propylcarbamoylsulfamoyl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid

Suppliers and Price of Fonsartan free acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Fonsartan free acid

Chemical Property:

XLogP3:5.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:12
Exact Mass:544.18141248
Heavy Atom Count:37
Complexity:844

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3S(=O)(=O)NC(=O)NCCC)C(=O)O)SC

Technology Process of Fonsartan free acid

There total 22 articles about Fonsartan free acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 144628-51-3
ethyl 2-butyl-4-(methylthio)-1-[[2'-[[[(propylamino)-carbonyl]-amino]-sulfonyl]-(1,1'-biphenyl)-4-yl]-methyl]-1H-imidazole-5-carboxylate

: 144628-52-4
2-butyl-4-(methylthio)-1-[[2'-((((propylamino)-carbonyl)-amino)-sulfonyl)-(1,1'-biphenyl)-4-yl]-methyl]-1H-imidazole-5-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; for 18h; Ambient temperature;
DOI:10.1055/s-1996-4383

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 144628-52-4
2-butyl-4-(methylthio)-1-[[2'-((((propylamino)-carbonyl)-amino)-sulfonyl)-(1,1'-biphenyl)-4-yl]-methyl]-1H-imidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / aq. Na₂CO₃, triphenylphosphine, palladium acetate / ethanol; toluene / 4 h / Heating

2: 64 percent / N-bromosuccinimide, benzoyl peroxide / chlorobenzene / 1 h / 120 °C

3: K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

4: 81 percent / conc. HCl / ethanol / 2 h / Heating

5: 87 percent / K₂CO₃ / acetone / 2 h / Heating

6: 80 percent / 2N NaOH / ethanol / 24 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; Perbenzoic acid; palladium diacetate; sodium carbonate; potassium carbonate; triphenylphosphine; In ethanol; N,N-dimethyl-formamide; chlorobenzene; acetone; toluene;
DOI:10.1021/jm00013a013

Reference yield:

: 638-29-9
n-valeryl chloride

: 144628-52-4
2-butyl-4-(methylthio)-1-[[2'-((((propylamino)-carbonyl)-amino)-sulfonyl)-(1,1'-biphenyl)-4-yl]-methyl]-1H-imidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 75 percent / pyridine / CH₂Cl₂ / 0 °C

2: 87 percent / triethylamine / ethanol / 50 h / 0 °C

3: 72 percent / PCl₅, 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / Ambient temperature

4: K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

5: 81 percent / conc. HCl / ethanol / 2 h / Heating

6: 87 percent / K₂CO₃ / acetone / 2 h / Heating

7: 80 percent / 2N NaOH / ethanol / 24 h / Ambient temperature

With pyridine; hydrogenchloride; dmap; sodium hydroxide; phosphorus pentachloride; potassium carbonate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00013a013