5-bromo-2-methoxybenzamidine

Base Information

• Chemical Name: 5-bromo-2-methoxybenzamidine
• CAS No.: 144650-00-0
• Molecular Formula: C8H9BrN2O
• Molecular Weight: 229.076
• Mol file: 144650-00-0.mol

Synonyms:bromomethoxymethylaminonicotinicacid;5-bromo-2-methoxy-6-(methylamino)nicotinic acid;5-bromo-2-methoxy-6-methylaminopyridine-3-carboxylic acid;5-bromo-2-methoxy-6-methylamino-3-pyridinecarboxylic acid;5-bromo-2-methoxybenzamidine;

Chemical Property of 5-bromo-2-methoxybenzamidine

Chemical Property:

• PSA: 57.90000
• LogP: 3.48580

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-2-methoxy-benzamidine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-2-methoxybenzamidine

There total 1 articles about 5-bromo-2-methoxybenzamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

5-bromo-2-methoxybenzonitrile (144649-99-0) → 5-Bromo-2-methoxy-benzamidine (144650-00-0)

Guidance literature:

5-bromo-2-methoxybenzonitrile; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 4.83333h;

With hydrogenchloride; In tetrahydrofuran; water; at 0 - 20 ℃;

With sodium hydroxide; In water;

Reference yield: 65.0%

1,3-dihydroxyacetone dimer (62147-49-3) + 5-Bromo-2-methoxy-benzamidine (144650-00-0) → 2-(5-bromo-2-methoxyphenyl)-4-hydroxymethylimidazole (144650-02-2)

Guidance literature:

With ammonium hydroxide; ammonium chloride; at 80 ℃; for 0.5h;

DOI:10.1016/S0960-894X(00)00405-4

Reference yield:

concentrated aqueous ammonium hydroxide + 1,3-dihydroxy-acetone dimer + 5-Bromo-2-methoxy-benzamidine (144650-00-0) → 2-(5-Bromo-2-methoxyphenyl)-5-hydroxymethyl-imidazole (144650-02-2)

Guidance literature:

With ammonium chloride; In tetrahydrofuran;

upstream raw materials:

5-bromo-2-methoxybenzonitrile

Downstream raw materials:

2-(5-Bromo-2-methoxyphenyl)-5-hydroxymethyl-imidazole

2-(5-bromo-2-methoxyphenyl)-4-hydroxymethylimidazole

2-(5-bromo-2-methoxy-phenyl)-1H-imidazole-4-carbaldehyde

2-(5-Bromo-2-methoxy-phenyl)-5-chloromethyl-1H-imidazole

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