2-(4-Bromophenoxy)acetamide

Base Information

• Chemical Name: 2-(4-Bromophenoxy)acetamide
• CAS No.: 35368-75-3
• Molecular Formula: C8H8 Br N O2
• Molecular Weight: 230.061
• Hs Code.: 2924299090
• NSC Number: 190601
• DSSTox Substance ID: DTXSID50307273
• Wikidata: Q82054644
• Mol file: 35368-75-3.mol

Synonyms:2-(4-bromophenoxy)acetamide;35368-75-3;NSC190601;Oprea1_317353;CBDivE_001329;2-(4-bromophenoxyl)acetamide;SCHEMBL1432953;2-(4-Bromo-phenoxy)-acetamide;DTXSID50307273;IFFIYLGFSQQYFB-UHFFFAOYSA-N;HMS1578K04;MFCD00466099;STK035198;AKOS000190866;NSC-190601;2-(4-Bromophenoxy)acetamide, AldrichCPR;AS-43041;BB 0244345;FT-0768478;SR-01000510967;SR-01000510967-1;Z19725712

Chemical Property of 2-(4-Bromophenoxy)acetamide

Chemical Property:

• Vapor Pressure: 1.69E-06mmHg at 25°C
• Melting Point: 148-149 °C(Solv: ethanol (64-17-5))
• Boiling Point: 396.6°C at 760 mmHg
• PKA: 15.26±0.40(Predicted)
• Flash Point: 193.6°C
• PSA: 52.32000
• Density: 1.565g/cm³
• LogP: 2.01350
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 228.97384
• Heavy Atom Count: 12
• Complexity: 155

Purity/Quality:

99%min ^*data from raw suppliers

2-(4-Bromophenoxy)acetamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1OCC(=O)N)Br

Technology Process of 2-(4-Bromophenoxy)acetamide

There total 4 articles about 2-(4-Bromophenoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 2-(4-bromophenoxy)acetate (6964-29-0) → 2-(4-bromophenoxy)acetamide (35368-75-3)

Guidance literature:

With ammonia; In methanol; at 10 - 30 ℃; for 2.5h;

Reference yield: 70.0%

(4-bromophenoxy)acetic acid (1878-91-7) → 2-(4-bromophenoxy)acetamide (35368-75-3)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 67.0%

→ 2-(4-bromophenoxy)acetamide (35368-75-3)

Guidance literature:

With dihydrogen peroxide; sodium hydroxide; In water; at 80 ℃; for 4h;

upstream raw materials:

ethyl 2-(4-bromophenoxy)acetate

4-bromo-phenol

(4-bromophenoxy)acetic acid

Downstream raw materials:

2-[4-(6-chloro-3-formyl-1H-indol-5-yl)phenoxy]acetamide

Refernces

• 1、 -. "INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK". Paragraph 1027. . Retrieved 2013/10/22.