(4-BROMOPHENOXY)ACETIC ACID ETHYL ESTER

Base Information

• Chemical Name: (4-BROMOPHENOXY)ACETIC ACID ETHYL ESTER
• CAS No.: 6964-29-0
• Molecular Formula: C10H11 Br O3
• Molecular Weight: 259.1
• Hs Code.: 2918990090
• Mol file: 6964-29-0.mol

Synonyms:Aceticacid, (4-bromophenoxy)-, ethyl ester (9CI); Acetic acid, (p-bromophenoxy)-,ethyl ester (7CI,8CI); (4-Bromophenoxy)acetic acid ethyl ester; Ethyl2-(4-bromophenoxy)acetate; Ethyl 4-bromophenoxyacetate; NSC 66305

Chemical Property of (4-BROMOPHENOXY)ACETIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 0.00091mmHg at 25°C
• Boiling Point: 303.8°Cat760mmHg
• Flash Point: 137.5°C
• PSA: 35.53000
• Density: 1.418g/cm³
• LogP: 2.39100

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl(4-Bromophenoxy)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-BROMOPHENOXY)ACETIC ACID ETHYL ESTER

There total 11 articles about (4-BROMOPHENOXY)ACETIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

4-bromo-phenol (106-41-2) + chloroacetic acid ethyl ester (105-39-5) → ethyl 2-(4-bromophenoxy)acetate (6964-29-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield: 93.0%

4-bromo-phenol (106-41-2) + ethyl bromoacetate (105-36-2) → ethyl 2-(4-bromophenoxy)acetate (6964-29-0)

Guidance literature:

With potassium carbonate; In acetonitrile; at 70 ℃; for 16h;

DOI:10.1021/acs.jmedchem.8b00152

Reference yield: 85.0%

(4-bromophenoxy)acetic acid (1878-91-7) + ethanol (64-17-5) → ethyl 2-(4-bromophenoxy)acetate (6964-29-0)

Guidance literature:

With acetyl chloride; at 80 ℃; for 24h; Cooling with ice;

DOI:10.1002/bio.3482

upstream raw materials:

phenoxyacetic acid ethyl ester

4-bromo-phenol

chloroacetic acid ethyl ester

ethyl bromoacetate

Downstream raw materials:

ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)acetate

2-(4-bromophenoxy)acetic acid hydrazide

ethyl 2-(1,1'-biphenyl-3'-(4-biphenylmethyl)-4'-ol-4-oxy) acetate

ethyl 2-(1,1'-biphenyl-3'-cyclohexylmethyl-4'-ol-4-oxy) acetate

Refernces

• 1、 Al-Ostoot, Fares Hezam,Khanum, Shaukath Ara,M, Pallavi H,Vivek, Hamse Kameshwar. "Design, docking, synthesis, and characterization of novel N'(2-phenoxyacetyl) nicotinohydrazide and N'(2-phenoxyacetyl)isonicotinohydrazide derivatives as anti-inflammatory and analgesic agents". . . Retrieved 2021/09/14.
• 2、 Al-Ostoot, Fares Hezam,Ara Khanum, Shaukath,Grisha, S.,Mohammed, Yasser Hussein Eissa,Vivek, H. K.,Zabiulla. "Molecular docking and synthesis of caffeic acid analogous and its anti-inflammatory, analgesic and ulcerogenic studies". . . Retrieved 2020/12/25.