2-aMino-4-Methoxybenzenethiol

Base Information

• Chemical Name: 2-aMino-4-Methoxybenzenethiol
• CAS No.: 14482-32-7
• Molecular Formula: C7H9NOS
• Molecular Weight: 155.221
• Hs Code.: 2930909899
• DSSTox Substance ID: DTXSID30276059
• Nikkaji Number: J3.141.232C
• Wikidata: Q82006378
• Mol file: 14482-32-7.mol

Synonyms:Benzenethiol,2-amino-4-methoxy;2-amino-4-methoxy-thiophenol;2-amino-4-methoxy-benzenethiol;

Chemical Property of 2-aMino-4-Methoxybenzenethiol

Chemical Property:

• Melting Point: 47 °C
• Boiling Point: 122 °C(Press: 0.5 Torr)
• PKA: 7.98±0.11(Predicted)
• PSA: 74.05000
• Density: 1.209±0.06 g/cm3(Predicted)
• LogP: 2.14730
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 155.04048508
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-4-methoxybenzenethiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)S)N

Technology Process of 2-aMino-4-Methoxybenzenethiol

There total 7 articles about 2-aMino-4-Methoxybenzenethiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.9%

2-chloro-5-methoxynitrobenzene (10298-80-3) → 2-amino-4-methoxybenzenethiol (14482-32-7)

Guidance literature:

2-chloro-5-methoxynitrobenzene; With sodium sulfide; In water; for 20h; Heating / reflux;

With hydrogenchloride; In water; at 20 ℃; pH=7;

Reference yield: 85.0%

2-amino-5-methoxybenzothiazole (54346-87-1) → 2-amino-4-methoxybenzenethiol (14482-32-7)

Guidance literature:

With sodium hydroxide; Heating;

DOI:10.1248/cpb.45.1008

Reference yield: 83.0%

5-methoxy-2-methylbenzo[d]thiazole (2941-69-7) → 2-amino-4-methoxybenzenethiol (14482-32-7)

Guidance literature:

With sodium hydroxide; In ethylene glycol; for 3h; Heating;

DOI:10.1021/jm000542r

upstream raw materials:

4,4′-dimethoxy-2,2′-dinitro-diphenyl disulfide

2-chloro-5-methoxynitrobenzene

2-amino-5-methoxybenzothiazole

5-methoxy-2-methylbenzo[d]thiazole

Downstream raw materials:

5-[(2-amino-4-methoxyphenyl)sulfanyl]pyrimidine-2,4(1H,3H)-dione

5-methoxy-1,3-benzothiazole

2-[(2-amino-4-methoxyphenyl)disulfanyl]-4-methoxyaniline