2-[4-[[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino](4-methoxyphenyl)methyl]-2-methylphenoxy]acetic acid

Base Information

Chemical Name:2-[4-[[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino](4-methoxyphenyl)methyl]-2-methylphenoxy]acetic acid
CAS No.:145089-11-8
Molecular Formula:C₃₂H₂₉NO₆
Molecular Weight:523.585
Hs Code.:
DSSTox Substance ID:DTXSID401114670
Mol file:145089-11-8.mol

Synonyms:DTXSID401114670;145089-11-8;2-[4-[[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino](4-methoxyphenyl)methyl]-2-methylphenoxy]acetic acid

Suppliers and Price of 2-[4-[[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino](4-methoxyphenyl)methyl]-2-methylphenoxy]acetic acid

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Chemical Property of 2-[4-[[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino](4-methoxyphenyl)methyl]-2-methylphenoxy]acetic acid

Chemical Property:

XLogP3:6.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:523.19948764
Heavy Atom Count:39
Complexity:791

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C=CC(=C1)C(C2=CC=C(C=C2)OC)NC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35)OCC(=O)O

Technology Process of 2-[4-[[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino](4-methoxyphenyl)methyl]-2-methylphenoxy]acetic acid

There total 6 articles about 2-[4-[[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino](4-methoxyphenyl)methyl]-2-methylphenoxy]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 84418-43-9
9-fluorenylmethyl carbamate

: 115057-35-7
<4-<(4-methoxyphenyl)methyl>-2-methylphenoxy>acetic acid

: 145089-11-8
<4-<<<9H-fluoren-9-yl-methoxycarbonyl>amino>(4-methoxyphenyl)methyl>-2-methylphenoxy>acetic acid

Guidance literature:: With sulfuric acid; acetic acid; for 1.5h;
DOI:10.1135/cccc19921707

Reference yield:

: 2989-17-5
methyl 2-methylphenoxy acetate

: 145089-11-8
<4-<<<9H-fluoren-9-yl-methoxycarbonyl>amino>(4-methoxyphenyl)methyl>-2-methylphenoxy>acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / AlCl₃ / 1,2-dichloro-ethane / 50 °C

2: 83 percent / 0.5 M aq. NaOH / dioxane / Ambient temperature

3: 84 percent / aq. NaOH, NaBH₄ / dioxane

4: 69 percent / glacial AcOH, H₂SO₄ / 1.5 h

With sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; sulfuric acid; acetic acid; In 1,4-dioxane; 1,2-dichloro-ethane;
DOI:10.1135/cccc19921707

Reference yield:

: 115057-32-4
methyl 4-(4'-methoxybenzoyl)-2-methylphenoxyacetate

: 145089-11-8
<4-<<<9H-fluoren-9-yl-methoxycarbonyl>amino>(4-methoxyphenyl)methyl>-2-methylphenoxy>acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / 0.5 M aq. NaOH / dioxane / Ambient temperature

2: 84 percent / aq. NaOH, NaBH₄ / dioxane

3: 69 percent / glacial AcOH, H₂SO₄ / 1.5 h

With sodium hydroxide; sodium tetrahydroborate; sulfuric acid; acetic acid; In 1,4-dioxane;
DOI:10.1135/cccc19921707