1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-4-oxo-5-(trimethylsilyl)-2-(triphenylsilyl)-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2S)-

Base Information

Chemical Name:1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-4-oxo-5-(trimethylsilyl)-2-(triphenylsilyl)-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2S)-
CAS No.:145238-74-0
Molecular Formula:C43H51NO3Si2
Molecular Weight:686.054
Hs Code.:
Mol file:145238-74-0.mol

1(2H)-Pyridinecarboxylic acid,
3,4-dihydro-4-oxo-5-(trimethylsilyl)-2-(triphenylsilyl)-,
(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2S)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-4-oxo-5-(trimethylsilyl)-2-(triphenylsilyl)-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2S)-

Chemical Property:

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Technology Process of 1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-4-oxo-5-(trimethylsilyl)-2-(triphenylsilyl)-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2S)-

There total 1 articles about 1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-4-oxo-5-(trimethylsilyl)-2-(triphenylsilyl)-, (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-Methoxy-1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-trimethylsilanyl-pyridinium; chloride

: triphenylsilylmagnesium chloride

: 145238-74-0
1-((1R,2S,5R)-8-phenylmenthoxycarbonyl)-5-trimethylsilyl-(S)-2-triphenylsilyl-2,3-dihydro-4-pyridone

: 1-((1R,2S,5R)-8-phenylmenthoxycarbonyl)-5-trimethylsilyl-(R)-2-triphenylsilyl-2,3-dihydro-4-pyridone

Guidance literature:: 4-Methoxy-1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-trimethylsilanyl-pyridinium; chloride; triphenylsilylmagnesium chloride; In tetrahydrofuran; toluene; at -85 - 20 ℃;

With oxalic acid; In tetrahydrofuran; toluene; at 20 ℃;

Reference yield:

: 145238-74-0
1-((1R,2S,5R)-8-phenylmenthoxycarbonyl)-5-trimethylsilyl-(S)-2-triphenylsilyl-2,3-dihydro-4-pyridone

: (S)-4-hydroxy-1-((1R,2S,5R)-8-phenylmenthoxycarbonyl)-(S)-2-triphenylsilyl-1,2,3,4-tetrahydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: HBr, HOAc

2: 98 percent / NaBH₄, CeCl₃ / methanol

3: 1.) BF₃*OEt₂, 2.) H₂O / 1.) toluene, -23 deg C, 5 min

With sodium tetrahydroborate; cerium(III) chloride; boron trifluoride diethyl etherate; water; hydrogen bromide; acetic acid; In methanol;
DOI:10.1021/ja00053a050

Reference yield:

: 145238-74-0
1-((1R,2S,5R)-8-phenylmenthoxycarbonyl)-5-trimethylsilyl-(S)-2-triphenylsilyl-2,3-dihydro-4-pyridone

: 145238-77-3
(R)-4-hydroxy-1-((1R,2S,5R)-8-phenylmenthoxycarbonyl)-(S)-2-triphenylsilyl-1,2,3,4-tetrahydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: HBr, HOAc

2: 98 percent / NaBH₄, CeCl₃ / methanol

With sodium tetrahydroborate; cerium(III) chloride; hydrogen bromide; acetic acid; In methanol;
DOI:10.1021/ja00053a050