1,8-Naphthyridine-2,7-diamine

Base Information

• Chemical Name: 1,8-Naphthyridine-2,7-diamine
• CAS No.: 145325-89-9
• Molecular Formula: C8H8N4
• Molecular Weight: 160.17600
• Hs Code.: 2933990090
• ChEMBL ID: CHEMBL4513776
• DSSTox Substance ID: DTXSID50459726
• Nikkaji Number: J1.655.405G
• Wikidata: Q82283554
• Mol file: 145325-89-9.mol

Synonyms:1,8-naphthyridine-2,7-diamine

Chemical Property of 1,8-Naphthyridine-2,7-diamine

Chemical Property:

• Melting Point: 222-223 °C
• Boiling Point: 395.5±37.0 °C(Predicted)
• PKA: 6.58±0.30(Predicted)
• PSA: 79.28000
• Density: 1.398±0.06 g/cm3(Predicted)
• LogP: 0.65440
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 160.074896272
• Heavy Atom Count: 12
• Complexity: 145

Purity/Quality:

99% ,98%,Electron Grade , ^*data from raw suppliers

[1,8]NAPHTHYRIDINE-2,7-DIAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC2=C1C=CC(=N2)N)N

Technology Process of 1,8-Naphthyridine-2,7-diamine

There total 10 articles about 1,8-Naphthyridine-2,7-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-amino-7-azido-1,8-naphthyridine (898258-02-1) → 2,7-bisamino-1,8-naphthyridine (145325-89-9)

Guidance literature:

With acetic acid; zinc; for 3h; Heating;

DOI:10.3390/10080929

Reference yield: 95.0%

N-(4-methoxybenzyl)-2,7-diamino-1,8-naphthyridine (861441-28-3) → 2,7-bisamino-1,8-naphthyridine (145325-89-9)

Guidance literature:

With hydrogenchloride; for 2h; Heating;

DOI:10.1055/s-2005-868507

Reference yield: 74.0%

2-acetylamino-7-chloro-1,8-naphthyridine (53788-34-4) → 2,7-bisamino-1,8-naphthyridine (145325-89-9)

Guidance literature:

With ammonia; In ethanol; at 180 ℃; for 24h;

DOI:10.1021/ja010638q

upstream raw materials:

2-acetylamino-7-chloro-1,8-naphthyridine

2,7-dichloro-1,8-naphthyridine

N-(4-methoxybenzyl)-2,7-diamino-1,8-naphthyridine

2-amino-7-azido-1,8-naphthyridine

Downstream raw materials:

2,7-bis-(phenylazo)-1,8-naphthyridine

2,7-bis(diphenylphosphorylamino)-1,8-naphthyridine

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