Bis(2-phenylethyl)phosphinic acid

Base Information

• Chemical Name: Bis(2-phenylethyl)phosphinic acid
• CAS No.: 14561-21-8
• Molecular Formula: C16H19O2P
• Molecular Weight: 274.299
• DSSTox Substance ID: DTXSID70568546
• Wikidata: Q82454832
• Mol file: 14561-21-8.mol

Synonyms:bis(2-phenylethyl)phosphinic acid;14561-21-8;Diphenethylphosphinic acid;SCHEMBL6030731;DTXSID70568546;NIRBJNRGTKTFRV-UHFFFAOYSA-N;Di-(2-phenylethyl)phosphinic Acid

Chemical Property of Bis(2-phenylethyl)phosphinic acid

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 274.11226684
• Heavy Atom Count: 19
• Complexity: 265

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CCP(=O)(CCC2=CC=CC=C2)O

Technology Process of Bis(2-phenylethyl)phosphinic acid

There total 12 articles about Bis(2-phenylethyl)phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

bis(2-phenylethyl)phosphine oxide (27440-52-4) → Di-(2-phenylethyl)phosphinic Acid (14561-21-8)

Guidance literature:

With dihydrogen peroxide; In acetone; at 20 ℃; for 3h;

DOI:10.1007/BF02251545

Reference yield: 83.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) → Di-(2-phenylethyl)phosphinic Acid (14561-21-8) + bis(2-phenylethyl)phosphine oxide (27440-52-4) + tri(2-phenylethyl)phosphine oxide (29701-83-5)

Guidance literature:

With phosphorus; potassium hydroxide; hydroquinone; In water; dimethyl sulfoxide; for 0.0666667h; microwave irradiation;

DOI:10.1134/S1070363207030140

Reference yield: 64.0%

bis(2-phenylethyl)phosphine oxide (27440-52-4) + syringic aldehyde (134-96-3) → Di-(2-phenylethyl)phosphinic Acid (14561-21-8) + bis(2-phenylethyl)[hydroxy(4-hydroxy-3,5-dimethoxyphenyl)methyl]phosphine oxide

Guidance literature:

In 1,4-dioxane; at 20 ℃; for 40h;

DOI:10.1023/B:RUGC.0000015976.82173.42

upstream raw materials:

1,1-Diphenylethylene

phenethylmagnesium bromide

phosphonic acid diethyl ester

bis(2-phenylethyl)phosphine oxide

Downstream raw materials:

diphenethylphosphinylchloride

Bis-(p-nitrophenaethyl)-phosphinsaeure