4-Hydroxy-1,3-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 3-ethyl ester

Base Information

• Chemical Name: 4-Hydroxy-1,3-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 3-ethyl ester
• CAS No.: 146256-99-7
• Molecular Formula: C12H21NO5
• Molecular Weight: 259.29900
• Mol file: 146256-99-7.mol

Synonyms:4-hydroxy-pyrrolidine-1,3-dicarboxylic acid 1-tert.-butylester 3-ethylester;Ethyl 1-Boc-4-hydroxypyrrolidine-3-carboxylate;4-hydroxy-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester;

Chemical Property of 4-Hydroxy-1,3-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 3-ethyl ester

Chemical Property:

• PSA: 76.07000
• LogP: 0.71520

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-2-fluoro-5-methoxybenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-Hydroxy-1,3-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 3-ethyl ester

There total 1 articles about 4-Hydroxy-1,3-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 3-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.9%

4-oxo-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (146256-98-6) → tert-butyl 3-ethyl 4-hydroxypyrrolidine-1,3-dicarboxylate (146256-99-7,1523541-94-7,849935-85-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 10 ℃; for 0.833333h;

DOI:10.1016/j.ejmech.2015.09.030

Reference yield: 91.0%

tert-butyl 3-ethyl 4-hydroxypyrrolidine-1,3-dicarboxylate (146256-99-7,1523541-94-7,849935-85-9) → 2,5-Dihydro-pyrrole-1,3-dicarboxylic acid 1-tert-butylester 3-ethyl ester (146257-00-3)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In toluene; at 20 ℃; for 12h;

DOI:10.1021/ja000093k

Reference yield:

tert-butyl 3-ethyl 4-hydroxypyrrolidine-1,3-dicarboxylate (146256-99-7,1523541-94-7,849935-85-9) → 4-(1-phenyl-ethylamino)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / PPh₃; diethyl azodicarboxylate / toluene / 12 h / 20 °C

2: H₂O / 67 h / 55 °C

With triphenylphosphine; diethylazodicarboxylate; In water; toluene; 1: Dehydration / 2: Addition;

DOI:10.1021/ja000093k

upstream raw materials:

4-oxo-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

Downstream raw materials:

2,5-Dihydro-pyrrole-1,3-dicarboxylic acid 1-tert-butylester 3-ethyl ester

(3S,4R)-1-(N-tert-butoxycarbonyl)-3-[(1'R)-phenylethylamino]-4-ethoxycarbonylpyrrolidine

C₇H₁₃NO₃

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