Ethyl N-Boc-2,5-dihydropyrrole-3-carboxylate

Base Information

Chemical Name:Ethyl N-Boc-2,5-dihydropyrrole-3-carboxylate
CAS No.:146257-00-3
Molecular Formula:C12H19NO4
Molecular Weight:241.28400
Hs Code.:
European Community (EC) Number:860-350-2
DSSTox Substance ID:DTXSID00707421
Nikkaji Number:J1.337.494E
Wikidata:Q82641219
Mol file:146257-00-3.mol

Synonyms:146257-00-3;Ethyl N-Boc-2,5-dihydropyrrole-3-carboxylate;1-tert-Butyl 3-ethyl 1H-pyrrole-1,3(2H,5H)-dicarboxylate;1-O-tert-butyl 3-O-ethyl 2,5-dihydropyrrole-1,3-dicarboxylate;1-(tert-Butyl) 3-ethyl 2,5-dihydro-1H-pyrrole-1,3-dicarboxylate;MFCD11973978;1-tert-Butyl 3-ethyl 2,5-dihydro-1H-pyrrole-1,3-dicarboxylate;EthylN-Boc-2,5-dihydropyrrole-3-carboxylate;SCHEMBL6958805;DTXSID00707421;HOOXYTICVUYNKS-UHFFFAOYSA-N;AMY32010;WFA25700;AKOS022185456;1H-Pyrrole-1,3-dicarboxylic acid, 2,5-dihydro-, 1-(1,1-dimethylethyl) 3-ethyl ester;AS-32389;SY027395;CS-0079118;FT-0747962;EN300-6995428;A858336;3-Pyrroline-1,3-dicarboxylic acid 1-tert-butyl 3-ethyl ester;2,5-dihydro-pyrrole-1,3-dicarboxylic acid 1-tert.-butylester 3-ethyl ester;3-Ethyl 1-(2-methyl-2-propanyl) 2,5-dihydro-1H-pyrrole-1,3-dicarboxylate;1-tert-butyl 3-ethyl 1H-pyrrole-1,3(2H,5H)-dicarboxylate

Suppliers and Price of Ethyl N-Boc-2,5-dihydropyrrole-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
EthylN-Boc-2,5-dihydropyrrole-3-carboxylate
10mg
$ 45.00

Crysdot
1-tert-Butyl3-ethyl1H-pyrrole-1,3(2H,5H)-dicarboxylate 97%
5g
$ 424.00

Chemenu
1-(tert-butyl)3-ethyl2,5-dihydro-1H-pyrrole-1,3-dicarboxylate 97%
5g
$ 400.00

Alichem
1-tert-Butyl3-ethyl1H-pyrrole-1,3(2H,5H)-dicarboxylate
1g
$ 239.99

Alichem
1-tert-Butyl3-ethyl1H-pyrrole-1,3(2H,5H)-dicarboxylate
5g
$ 712.98

AK Scientific
EthylN-Boc-2,5-dihydropyrrole-3-carboxylate
5g
$ 651.00

Total 24 raw suppliers

Chemical Property of Ethyl N-Boc-2,5-dihydropyrrole-3-carboxylate

Chemical Property:

PSA：55.84000
LogP:1.66450
XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:241.13140809
Heavy Atom Count:17
Complexity:341

Purity/Quality:

97% ^*data from raw suppliers

EthylN-Boc-2,5-dihydropyrrole-3-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CCN(C1)C(=O)OC(C)(C)C

Technology Process of Ethyl N-Boc-2,5-dihydropyrrole-3-carboxylate

There total 4 articles about Ethyl N-Boc-2,5-dihydropyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 146256-99-7,1523541-94-7,849935-85-9
tert-butyl 3-ethyl 4-hydroxypyrrolidine-1,3-dicarboxylate

: 146257-00-3
2,5-Dihydro-pyrrole-1,3-dicarboxylic acid 1-tert-butylester 3-ethyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; at 20 ℃; for 12h;
DOI:10.1021/ja000093k

Reference yield:

: 146256-98-6
4-oxo-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

: 146257-00-3
2,5-Dihydro-pyrrole-1,3-dicarboxylic acid 1-tert-butylester 3-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₃CN; HCl / methanol

2: 91 percent / PPh₃; diethyl azodicarboxylate / toluene / 12 h / 20 °C

With hydrogenchloride; sodium cyanoborohydride; triphenylphosphine; diethylazodicarboxylate; In methanol; toluene; 1: Reduction / 2: Dehydration;
DOI:10.1021/ja000093k