2-{[(4-Methylphenyl)amino]methyl}phenol

Base Information

• Chemical Name: 2-{[(4-Methylphenyl)amino]methyl}phenol
• CAS No.: 14674-88-5
• Molecular Formula: C14H15NO
• Molecular Weight: 213.279
• Hs Code.: 2922498590
• European Community (EC) Number: 653-609-4
• Nikkaji Number: J1.411.431I
• ChEMBL ID: CHEMBL1548742
• Mol file: 14674-88-5.mol

Synonyms:2-{[(4-methylphenyl)amino]methyl}phenol;14674-88-5;2-([(4-Methylphenyl)amino]methyl)phenol;2-[(4-methylanilino)methyl]phenol;SMR000131928;MLS000521520;SCHEMBL802037;2-((P-tolylamino)methyl)phenol;CHEMBL1548742;2-(4-Methylanilinomethyl)phenol;N-(2-hydroxybenzyl)-p-toluidine;HMS2464M08;MFCD00086756;STL254159;AKOS000242822;BS-3119;SB79306;2-((p-Tolylamino)methyl)phenol, AldrichCPR;CS-0314260;MLS000521520-02;SR-01000087113;SR-01000087113-1;2-((4-methyl-phenylamino)methyl)phenol, C~14~H~15~NO

Chemical Property of 2-{[(4-Methylphenyl)amino]methyl}phenol

Chemical Property:

• PSA: 32.26000
• LogP: 3.38570
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 213.115364102
• Heavy Atom Count: 16
• Complexity: 199

Purity/Quality:

99% ^*data from raw suppliers

2-{[(4-methylphenyl)amino]methyl}phenol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NCC2=CC=CC=C2O

Technology Process of 2-{[(4-Methylphenyl)amino]methyl}phenol

There total 18 articles about 2-{[(4-Methylphenyl)amino]methyl}phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-salicylidene-p-methylaniline (782-76-3) → 2-((p-toluidino)methyl)phenol (14674-88-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 0.5h; Ambient temperature;

Reference yield: 94.0%

N-(o-hydroxybenzylidene)-p-toluidine (782-76-3,116546-09-9,117909-26-9) → 2-((p-toluidino)methyl)phenol (14674-88-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.666667h;

DOI:10.1002/jhet.533

Reference yield: 80.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + p-toluidine (106-49-0,12221-03-3) + phenol (108-95-2,27073-41-2) → 2-((p-toluidino)methyl)phenol (14674-88-5)

Guidance literature:

In toluene; at 70 ℃; for 5h;

DOI:10.1039/c4cp02053g

upstream raw materials:

2(2-hydroxyphenyl)-N-(4-methylphenyl) nitrone

N-salicylidene-p-methylaniline

salicylic alcohol

p-toluidine

Downstream raw materials:

2-(3-nitrophenyl)-3-p-tolyl-3,4-dihydro-2H-benzo[e][1,3]oxazine

2-(4-nitrophenyl)-3-p-tolyl-3,4-dihydro-2H-benzo[e][1,3]oxazine

2-(4-nitrophenyl)-3-m-tolyl-3,4-dihydro-2H-benzo[e][1,3]oxazine

2-(2-nitrophenyl)-3-p-tolyl-3,4-dihydro-2H-benzo[e][1,3]oxazine