[1,1'-Biphenyl]-2-sulfonamide, 4'-[[3-butyl-1-(2-chloro-5-nitrophenyl)-1,5-dihydro-5-oxo-4H-1,2,4-triazol -4-yl]methyl]-

Base Information

Chemical Name:[1,1'-Biphenyl]-2-sulfonamide, 4'-[[3-butyl-1-(2-chloro-5-nitrophenyl)-1,5-dihydro-5-oxo-4H-1,2,4-triazol -4-yl]methyl]-
CAS No.:146949-05-5
Molecular Formula:C25H24ClN5O5S
Molecular Weight:542.015
Hs Code.:
Mol file:146949-05-5.mol

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Chemical Property of [1,1'-Biphenyl]-2-sulfonamide, 4'-[[3-butyl-1-(2-chloro-5-nitrophenyl)-1,5-dihydro-5-oxo-4H-1,2,4-triazol -4-yl]methyl]-

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Technology Process of [1,1'-Biphenyl]-2-sulfonamide, 4'-[[3-butyl-1-(2-chloro-5-nitrophenyl)-1,5-dihydro-5-oxo-4H-1,2,4-triazol -4-yl]methyl]-

There total 7 articles about [1,1'-Biphenyl]-2-sulfonamide, 4'-[[3-butyl-1-(2-chloro-5-nitrophenyl)-1,5-dihydro-5-oxo-4H-1,2,4-triazol -4-yl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 146949-04-4
5-n-butyl-4-<<2'-(N-tert-butylsulfamoyl)biphenyl-4-yl>methyl>-2-(2-chloro-5-nitrophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

: 146949-05-5
5-n-butyl-2-(2-chloro-5-nitrophenyl)-2,4-dihydro-4-<(2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

Guidance literature:

Reference yield:

: 146949-06-6
ethyl N-carbethoxy-valerimidate

: 146949-05-5
5-n-butyl-2-(2-chloro-5-nitrophenyl)-2,4-dihydro-4-<(2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / toluene / 15 h / 90 °C

2: 1.) NaH / 1.) DMF, 50 deg C, 1 h, 2.) DMF, 50 deg C, 1.5 h

3: 74 percent / anisole, TFA / 48 h / Ambient temperature

With sodium hydride; methoxybenzene; triethylamine; trifluoroacetic acid; In toluene;
DOI:10.1021/jm00052a006

Reference yield:

: 100367-78-0
(2-bromo-5-nitrophenyl)hydrazine

: 146949-05-5
5-n-butyl-2-(2-chloro-5-nitrophenyl)-2,4-dihydro-4-<(2'-sulfamoylbiphenyl-4-yl)methyl>-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / toluene / 15 h / 90 °C

2: 1.) NaH / 1.) DMF, 50 deg C, 1 h, 2.) DMF, 50 deg C, 1.5 h

3: 32 percent / KF, CuI / dimethylformamide / 12 h / 120 °C

4: 74 percent / anisole, TFA / 48 h / Ambient temperature

With potassium fluoride; copper(l) iodide; sodium hydride; methoxybenzene; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00052a006