L-Cysteine, S-[[2-carboxy-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxy-3-meth ylphenyl]methyl]-N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, 1-methyl ester

Base Information

Chemical Name:L-Cysteine, S-[[2-carboxy-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxy-3-meth ylphenyl]methyl]-N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, 1-methyl ester
CAS No.:147215-01-8
Molecular Formula:C28H46N2O10SSi
Molecular Weight:630.832
Hs Code.:
Mol file:147215-01-8.mol

L-Cysteine,
S-[[2-carboxy-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxy-3-meth
ylphenyl]methyl]-N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, 1-methyl
ester

Synonyms:

Suppliers and Price of L-Cysteine, S-[[2-carboxy-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxy-3-meth ylphenyl]methyl]-N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, 1-methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Cysteine, S-[[2-carboxy-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxy-3-meth ylphenyl]methyl]-N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, 1-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

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Technology Process of L-Cysteine, S-[[2-carboxy-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxy-3-meth ylphenyl]methyl]-N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, 1-methyl ester

There total 5 articles about L-Cysteine, S-[[2-carboxy-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-methoxy-3-meth ylphenyl]methyl]-N-[N-[(1,1-dimethylethoxy)carbonyl]-L-seryl]-, 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 676347-09-4
methyl N-[N-tert-butoxycarbonyl-L-seryl]-S-[4-(tert-butyl)dimethylsilyloxy-6-methoxy-3-methyl-2-(4-nitrobenzyloxycarbonyl)benzyl]-L-cysteinate

: 147215-01-8
6-[[[(R)-2-[(S)-2-(1-tert-butoxyformamido)-3-hydroxypropionyl-amino]-2-(methoxycarbonyl)ethyl]thio]methyl]-3-(tert-butyldimethylsilyloxy)-5-methoxy-2-methylbenzoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 18h;
DOI:10.1021/jm0310232

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 147215-01-8
6-[[[(R)-2-[(S)-2-(1-tert-butoxyformamido)-3-hydroxypropionyl-amino]-2-(methoxycarbonyl)ethyl]thio]methyl]-3-(tert-butyldimethylsilyloxy)-5-methoxy-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / Et₃N / dimethylformamide / 0 °C

2.1: NBS / CCl₄ / 0.67 h / Heating; irradiation

2.2: 26 percent / Et₃N / CH₂Cl₂ / 2 h / 0 - 20 °C

3.1: H₂ / Pd/C / ethyl acetate / 18 h / 20 °C

With N-Bromosuccinimide; hydrogen; triethylamine; palladium on activated charcoal; In tetrachloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0310232

Reference yield:

: 676346-99-9
4-nitrobenzyl 3-hydroxy-5-methoxy-2,6-dimethylbenzoate

: 147215-01-8
6-[[[(R)-2-[(S)-2-(1-tert-butoxyformamido)-3-hydroxypropionyl-amino]-2-(methoxycarbonyl)ethyl]thio]methyl]-3-(tert-butyldimethylsilyloxy)-5-methoxy-2-methylbenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / Et₃N / dimethylformamide / 0 °C

2.1: NBS / CCl₄ / 0.67 h / Heating; irradiation

2.2: 26 percent / Et₃N / CH₂Cl₂ / 2 h / 0 - 20 °C

3.1: H₂ / Pd/C / ethyl acetate / 18 h / 20 °C

With N-Bromosuccinimide; hydrogen; triethylamine; palladium on activated charcoal; In tetrachloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0310232