6-(2-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

Base Information

Chemical Name:6-(2-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid
CAS No.:147283-47-4
Molecular Formula:C12H8ClNO3
Molecular Weight:249.653
Hs Code.:
European Community (EC) Number:888-851-1
DSSTox Substance ID:DTXSID101179077
Mol file:147283-47-4.mol

Synonyms:147283-47-4;6-(2-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid;6-(2-chlorophenyl)-2-oxo-1H-pyridine-3-carboxylic Acid;SCHEMBL7276461;DTXSID101179077;3-Pyridinecarboxylic acid, 6-(2-chlorophenyl)-1,2-dihydro-2-oxo-;AKOS010924139;AKOS037624742;VS-13661;CS-0246253;FT-0749256;EN300-320939;6-(2-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylicacid;6-(2-Chlorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid

Suppliers and Price of 6-(2-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 6-(2-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:249.0192708
Heavy Atom Count:17
Complexity:414

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C2=CC=C(C(=O)N2)C(=O)O)Cl

Technology Process of 6-(2-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

There total 1 articles about 6-(2-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.3%

: 147283-46-3
6-(2-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

: 147283-47-4
6-(2-chlorophenyl)pyrid-2-one-3-carboxylic acid

Guidance literature:: With hydrogen bromide; In water; acetic acid;

Reference yield:

: 147283-47-4
6-(2-chlorophenyl)pyrid-2-one-3-carboxylic acid

: 147283-34-9
2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: diphenyl-phosphinic acid; triethylamine / 1,4-dioxane / Heating

2: 1,4-dioxane / Heating

3: sodium hydride / 1.) DMF, RT, 2.) DMF, RT

4: hydrogen / palladium on activated charcoal / ethanol / 6 h / 2550.2 Torr

5: sodium methylate / methanol; ethanol / 18 h

With diphenyl-phosphinic acid; hydrogen; sodium methylate; sodium hydride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol;
DOI:10.1021/jm00046a015

Reference yield:

: 147283-47-4
6-(2-chlorophenyl)pyrid-2-one-3-carboxylic acid

: 147269-03-2
2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: diphenyl-phosphinic acid; triethylamine / 1,4-dioxane / Heating

2: 1,4-dioxane / Heating

3: sodium hydride / 1.) DMF, RT, 2.) DMF, RT

4: hydrogen / palladium on activated charcoal / ethanol / 6 h / 2550.2 Torr

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 4.5 h

With diphenyl-phosphinic acid; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol;
DOI:10.1021/jm00046a015