147283-46-3

Basic information

• Product Name: 3-Pyridinecarbonitrile, 6-(2-chlorophenyl)-1,2-dihydro-2-oxo-
• CAS NO: 147283-46-3
• Molecular Formula: C12H7ClN2O
• Molecular Weight: 230.653
• Mol File: 147283-46-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarbonitrile, 6-(2-chlorophenyl)-1,2-dihydro-2-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarbonitrile, 6-(2-chlorophenyl)-1,2-dihydro-2-oxo-(147283-46-3)
• EPA Substance Registry System: 3-Pyridinecarbonitrile, 6-(2-chlorophenyl)-1,2-dihydro-2-oxo-(147283-46-3)

Safety Data

• Hazardous Substances Data: 147283-46-3(Hazardous Substances Data)

Upstream product

• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 107-91-5 cyanoacetic acid amide 
• 75175-78-9 1-(2-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one 

Downstream Products

• 147283-47-4 6-(2-chlorophenyl)pyrid-2-one-3-carboxylic acid 
• 147283-34-9 2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide 
• 147269-03-2 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide 
• 147269-02-1 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide 
• 147267-17-2 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide 
• 147313-48-2 benzyl 6-(2-chlorophenyl)-2-oxo-1,2-dihydropyridin-3-ylcarbamate 
• 147283-48-5 2-[3-benzyloxycarbonylamino-6-(2-chlorophenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide 
• 1065267-37-9 5-bromo-6-(2-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 1160912-87-7 C₁₂H₅BrCl₂N₂ 
• 1065267-41-5 6-bromo-2-tert-butyl-7-(2-chlorophenyl)-8,8a-dihydropyrido[2,3-d]pyrimidin-4-amine 
• 1065267-44-8 6-bromo-2-tert-butyl-7-(2-chlorophenyl)-8,8a-dihydropyrido[2,3-d]pyrimidin-4(3H)-one 
• 1065267-48-2 6-bromo-2-tert-butyl-4-chloro-7-(2-chlorophenyl)-8,8a-dihydropyrido[2,3-d]pyrimidine 
• 1065267-53-9 6-bromo-2-tert-butyl-7-(2-chlorophenyl)-4-hydrazino-8,8a-dihydropyrido[2,3-d]pyrimidine 
• 1065267-31-3 9-bromo-5-tert-butyl-8-(2-chlorophenyl)pyrido[3,2-e][1,2,4]triazolo[4,3-c]pyrimidin-3(2H)-one 

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Nonpeptidic inhibitors of human leukocyte elastase. 2. Design, synthesis, and in vitro activity of a series of 3-amino-6-arylopyridin-2-one trifluoromethyl ketones

A series of potent nonpeptidic inhibitors of the enzyme human leukocyte elastase (HLE) is reported. These inhibitors contain a 3-amino-2-pyridone ring as a central template in which the pyridone carbonyl and 3-position NH group are thought to form important hydrogen bonding interactions with the Val-216 residue of HLE. Substitution of the 6-position of the pyridone ring by various alkyl and aryl groups was found to afford increases in the in vitro potency of these inhibitors. A 6-position phenyl group, compound 10f, was found to result in a large increase in binding affinity, which was not obtained when the phenyl group was placed in either the 4- or 5-position of the molecule. Compound 10f was found to have good selectivity for HLE over other proteolytic enzymes, with the exception of bovine pancreatic chymotrypsin (BPC). Substitution of the 6-phenyl group in these molecules was found to decrease binding affinity for BPC without adversely affecting affinity for HLE.