Technology Process of Oxazole, 4-[(1E)-3-(diphenylphosphinyl)-2-methyl-1-propenyl]-2-methyl-
There total 7 articles about Oxazole, 4-[(1E)-3-(diphenylphosphinyl)-2-methyl-1-propenyl]-2-methyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 94 percent / LiAlH4 / diethyl ether / 0.33 h / -78 °C
2: 91 percent / (COCl)2, DMSO, TEA / CH2Cl2
3: 86 percent / KOt-Bu / tetrahydrofuran / 0.33 h / -78 deg C --> 0 deg C
4: 100 percent / DIBAL-H / CH2Cl2 / 0.25 h / -78 °C
5: 82 percent / NBS, PPh3, 2-methyl-2-butene / CH2Cl2 / 0.33 h / -78 deg C to 0 deg C
6: tetrahydrofuran / 0.33 h / 0 °C
7: NaIO4 / various solvent(s); H2O / 0 °C
With
sodium periodate; N-Bromosuccinimide; lithium aluminium tetrahydride; 2-methyl-but-2-ene; oxalyl dichloride; TEA; potassium tert-butylate; diisobutylaluminium hydride; dimethyl sulfoxide; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1016/S0040-4039(00)77486-7
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 86 percent / KOt-Bu / tetrahydrofuran / 0.33 h / -78 deg C --> 0 deg C
2: 100 percent / DIBAL-H / CH2Cl2 / 0.25 h / -78 °C
3: 82 percent / NBS, PPh3, 2-methyl-2-butene / CH2Cl2 / 0.33 h / -78 deg C to 0 deg C
4: tetrahydrofuran / 0.33 h / 0 °C
5: NaIO4 / various solvent(s); H2O / 0 °C
With
sodium periodate; N-Bromosuccinimide; 2-methyl-but-2-ene; potassium tert-butylate; diisobutylaluminium hydride; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0040-4039(00)77486-7