Benzoic acid, 3-[4-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-3-butyl-4,5-dihydro-5- oxo-1H-1,2,4-triazol-1-yl]-4-chloro-, methyl ester

Base Information

Chemical Name:Benzoic acid, 3-[4-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-3-butyl-4,5-dihydro-5- oxo-1H-1,2,4-triazol-1-yl]-4-chloro-, methyl ester
CAS No.:147776-50-9
Molecular Formula:C27H27ClN4O5S
Molecular Weight:555.054
Hs Code.:
Mol file:147776-50-9.mol

Synonyms:

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Chemical Property of Benzoic acid, 3-[4-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-3-butyl-4,5-dihydro-5- oxo-1H-1,2,4-triazol-1-yl]-4-chloro-, methyl ester

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Technology Process of Benzoic acid, 3-[4-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-3-butyl-4,5-dihydro-5- oxo-1H-1,2,4-triazol-1-yl]-4-chloro-, methyl ester

There total 4 articles about Benzoic acid, 3-[4-[[2'-(aminosulfonyl)[1,1'-biphenyl]-4-yl]methyl]-3-butyl-4,5-dihydro-5- oxo-1H-1,2,4-triazol-1-yl]-4-chloro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 147776-49-6
5-n-butyl-4-[[2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl]-2-[5-(carbomethoxy)-2-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

: 147776-50-9
5-n-Butyl-2-[5-(carbomethoxy)-2-chlorophenyl]-2,4-dihydro-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-3H-1,2,4,-triazol-3-one

Guidance literature:

Reference yield:

: 146949-06-6
ethyl N-carbethoxy-valerimidate

: 147776-50-9
5-n-Butyl-2-[5-(carbomethoxy)-2-chlorophenyl]-2,4-dihydro-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-3H-1,2,4,-triazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / toluene / 15 h / 90 °C

2: 1.) NaH / 1.) DMF, 50 deg C, 1 h, 2.) DMF, 50 deg C, 1.5 h

3: anisole, TFA / Ambient temperature

With sodium hydride; methoxybenzene; triethylamine; trifluoroacetic acid; In toluene;
DOI:10.1021/jm00052a006

Reference yield:

: 89981-25-9
5-(carbomethoxy)-2-chlorophenylhydrazine

: 147776-50-9
5-n-Butyl-2-[5-(carbomethoxy)-2-chlorophenyl]-2,4-dihydro-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-3H-1,2,4,-triazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / toluene / 15 h / 90 °C

2: 1.) NaH / 1.) DMF, 50 deg C, 1 h, 2.) DMF, 50 deg C, 1.5 h

3: anisole, TFA / Ambient temperature

With sodium hydride; methoxybenzene; triethylamine; trifluoroacetic acid; In toluene;
DOI:10.1021/jm00052a006