Benzoic acid, 4-(phenylmethoxy)-, 4-butoxyphenyl ester

Base Information

• Chemical Name: Benzoic acid, 4-(phenylmethoxy)-, 4-butoxyphenyl ester
• CAS No.: 148731-13-9
• Molecular Formula: C24H24O4
• Molecular Weight: 376.452
• Mol file: 148731-13-9.mol

Synonyms:

Chemical Property of Benzoic acid, 4-(phenylmethoxy)-, 4-butoxyphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 4-(phenylmethoxy)-, 4-butoxyphenyl ester

There total 5 articles about Benzoic acid, 4-(phenylmethoxy)-, 4-butoxyphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-(benzyloxy)benzoic acid (1486-51-7) → 4-butoxyphenyl 4-(benzyloxy)benzoate (148731-13-9)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / DMF / CH₂Cl₂ / 1.5 h / Heating

2: NEt₃, 4-pyrrolidinopyridine / CH₂Cl₂ / 3 h / Heating

With thionyl chloride; 4-pyrrolidin-1-ylpyridine; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1002/hlca.19930760210

Reference yield:

4-(benzyloxy)benzoic acid chloride (1486-50-6) + 4-n-butoxyphenol (122-94-1) → 4-butoxyphenyl 4-(benzyloxy)benzoate (148731-13-9)

Guidance literature:

With 4-pyrrolidin-1-ylpyridine; triethylamine; In dichloromethane; for 3h; Yield given; Heating;

DOI:10.1002/hlca.19930760210

Reference yield:

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → 4-butoxyphenyl 4-(benzyloxy)benzoate (148731-13-9)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 90 °C

2: potassium hydroxide; water / ethanol / 1 h / Reflux

3: thionyl chloride / 1 h / Reflux

4: triethylamine / butanone / 3 h / 0 - 20 °C

With thionyl chloride; water; potassium carbonate; triethylamine; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; butanone;

DOI:10.1039/c3nj01414b

upstream raw materials:

4-(benzyloxy)benzoic acid chloride

4-n-butoxyphenol

p-(benzyloxy)benzoic acid

methyl 4-hydroxylbenzoate

Downstream raw materials:

4-n-butyloxyphenyl 4'-hydroxybenzoate