5-Pyrimidinecarboxylic acid, 1,4-dihydro-6-(3-hydroxypropyl)-2-methoxy-4-undecyl-, 4-[[imino[[(phenylmethoxy)carbonyl]amino]methyl][(phenylmethoxy)carb onyl]amino]butyl ester

Base Information

Chemical Name:5-Pyrimidinecarboxylic acid, 1,4-dihydro-6-(3-hydroxypropyl)-2-methoxy-4-undecyl-, 4-[[imino[[(phenylmethoxy)carbonyl]amino]methyl][(phenylmethoxy)carb onyl]amino]butyl ester
CAS No.:150252-71-4
Molecular Formula:C41H59N5O8
Molecular Weight:749.948
Hs Code.:

5-Pyrimidinecarboxylic acid,
1,4-dihydro-6-(3-hydroxypropyl)-2-methoxy-4-undecyl-,
4-[[imino[[(phenylmethoxy)carbonyl]amino]methyl][(phenylmethoxy)carb
onyl]amino]butyl ester

Synonyms:

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Chemical Property of 5-Pyrimidinecarboxylic acid, 1,4-dihydro-6-(3-hydroxypropyl)-2-methoxy-4-undecyl-, 4-[[imino[[(phenylmethoxy)carbonyl]amino]methyl][(phenylmethoxy)carb onyl]amino]butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Pyrimidinecarboxylic acid, 1,4-dihydro-6-(3-hydroxypropyl)-2-methoxy-4-undecyl-, 4-[[imino[[(phenylmethoxy)carbonyl]amino]methyl][(phenylmethoxy)carb onyl]amino]butyl ester

There total 5 articles about 5-Pyrimidinecarboxylic acid, 1,4-dihydro-6-(3-hydroxypropyl)-2-methoxy-4-undecyl-, 4-[[imino[[(phenylmethoxy)carbonyl]amino]methyl][(phenylmethoxy)carb onyl]amino]butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 150252-70-3
4-amino>methyl>-N-<(phenylmethoxy)carbonyl>amino>butyl 6-<3-<(tert-butyldimethylsilyl)oxy>propyl>-1,4-dihydro-2-methoxy-4-undecylpyrimidine-5-carboxylate

: 150252-71-4
4-amino>methyl>-N-<(phenylmethoxy)carbonyl>amino>butyl 1,4-dihydro-6-(3-hydroxypropyl)-2-methoxy-4-undecylpyrimidine-5-carboxylate

Guidance literature:: With hydrogen fluoride; In acetonitrile; for 1.5h; Ambient temperature;
DOI:10.1021/jo00067a014

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 150252-71-4
4-amino>methyl>-N-<(phenylmethoxy)carbonyl>amino>butyl 1,4-dihydro-6-(3-hydroxypropyl)-2-methoxy-4-undecylpyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Me₃SiCl, DIPEA, 2.) DIPEA / 1.) 1,2-dichloroethane, 40 deg C, 1 h, 2.) a) 0 deg C, 20 min, b) room temperature, 40 h

2: 53 percent / DMAP / benzene / 24 h / Heating

3: 2.) NaHCO₃ / 1.) piperidine / 1.) CH₂Cl₂, -20 deg C, 3 d, 2.) DMF, 55 deg C, 3 h

4: 88 percent / 50percent aq. HF / acetonitrile / 1.5 h / Ambient temperature

With chloro-trimethyl-silane; hydrogen fluoride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; piperidine; dmap; In acetonitrile; benzene;
DOI:10.1021/jo00067a014

Reference yield:

: (4-hydroxybutyl)guanidinium toluenesulfonate

: 150252-71-4
4-amino>methyl>-N-<(phenylmethoxy)carbonyl>amino>butyl 1,4-dihydro-6-(3-hydroxypropyl)-2-methoxy-4-undecylpyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Me₃SiCl, DIPEA, 2.) DIPEA / 1.) 1,2-dichloroethane, 40 deg C, 1 h, 2.) a) 0 deg C, 20 min, b) room temperature, 40 h

2: 53 percent / DMAP / benzene / 24 h / Heating

3: 2.) NaHCO₃ / 1.) piperidine / 1.) CH₂Cl₂, -20 deg C, 3 d, 2.) DMF, 55 deg C, 3 h

4: 88 percent / 50percent aq. HF / acetonitrile / 1.5 h / Ambient temperature

With chloro-trimethyl-silane; hydrogen fluoride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; piperidine; dmap; In acetonitrile; benzene;
DOI:10.1021/jo00067a014