3-(Pyrrolidin-3-yl)pyridine

Base Information

• Chemical Name: 3-(Pyrrolidin-3-yl)pyridine
• CAS No.: 150281-46-2
• Molecular Formula: C9H12N2
• Molecular Weight: 148.208
• Hs Code.: 2933990090
• European Community (EC) Number: 816-048-8
• DSSTox Substance ID: DTXSID80933903
• Nikkaji Number: J1.107.593B
• Mol file: 150281-46-2.mol

Synonyms:3-(pyrrolidin-3-yl)pyridine;150281-46-2;3-Pyrrolidin-3-ylpyridine;498548-11-1;3-pyrrolidin-3-yl-pyridine;(+)-3-(Pyrrolidin-3-yl)pyridine;3-(3-pyrrolidinyl)pyridine;Pyridine, 3-(3-pyrrolidinyl)-, (+)- (9CI);3-(3-pyrrolidinyl)pyridine dihydrochloride;498548-09-7;Pyridine,3-(3-pyrrolidinyl)-, (+)-;3-pyrrolidine-3-yl pyridine;3-(3-pyrrolidinyl) pyridine;3-(3-pyrrolidinyl)-pyridine;(4-Pyrrolidin-3-Yl)pyridine;SCHEMBL717702;DTXSID80933903;JNZDYUPZUHCHFK-UHFFFAOYSA-N;AR1448;MFCD01862540;AKOS009158456;SB33786;TS-01949;BB 0254820;CS-0200205;FT-0645388;FT-0681605;EN300-69088;3-FLUORO-4-METHOXYPHENYLMAGNESIUMBROMIDE;A827881;A884176;J-510970;F2148-0158

Chemical Property of 3-(Pyrrolidin-3-yl)pyridine

Chemical Property:

• Boiling Point: 267.4±28.0 °C(Predicted)
• PKA: 9.76±0.10(Predicted)
• PSA: 24.92000
• Density: 1.042±0.06 g/cm3(Predicted)
• LogP: 2.28930
• Storage Temp.: 2-8°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 148.100048391
• Heavy Atom Count: 11
• Complexity: 125

Purity/Quality:

98%min ^*data from raw suppliers

3-(pyrrolidin-3-yl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCC1C2=CN=CC=C2

Technology Process of 3-(Pyrrolidin-3-yl)pyridine

There total 4 articles about 3-(Pyrrolidin-3-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

3-[1-(phenylmethyl)-3-pyrrolidinyl]pyridine (145105-05-1) → 3-(pyrrolidin-3-yl)pyridine (150281-46-2,498548-09-7,498548-11-1)

Guidance literature:

Reference yield:

3-(3-pyridyl)pyrrole (76304-55-7) → 3-(pyrrolidin-3-yl)pyridine (150281-46-2,498548-09-7,498548-11-1)

Guidance literature:

With palladium; acetic acid; Hydrogenation;

Reference yield:

3-(1H-pyrrol-1-yl)pyridine (72692-99-0) → 3-(pyrrolidin-3-yl)pyridine (150281-46-2,498548-09-7,498548-11-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 700 - 720 °C

2: palladium; acetic acid / Hydrogenation

With palladium; acetic acid;

upstream raw materials:

3-(3-pyridyl)pyrrole

3-(1H-pyrrol-1-yl)pyridine

3-[1-(phenylmethyl)-3-pyrrolidinyl]pyridine

Downstream raw materials:

1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[3-(3-pyridinyl)-1-pyrrolidinyl]-1,8-naphthyridine-3-carboxylic acid

benzyl 3-pyridin-3-ylpyrrolidine-1-carboxylate

2-isopropyl-5-[(3-pyridin-3-ylpyrrolidin-1-yl)carbonyl]-1-[4-(trifluoromethoxy)phenyl]-1H-benzimidazole

3-[1-(4-iodobenzoyl)pyrrolidin-3-yl]pyridine

Refernces

• 1、 -. "BIARYL CARBOXAMIDES". Page/Page column 37-38. . Retrieved 2010/08/04.