72692-99-0

Basic information

• Product Name: 3-(1H-PYRROL-1-YL)PYRIDINE
• Synonyms: N(3-PYRIDYL)PYRROLE;1-(3-PYRIDYL)PYRROLE;3-(1H-PYRROL-1-YL)PYRIDINE;N-(PYRID-3-YL)PYRROLE;3-(1H-pyrrol-1-yl)pyridine hydrochloride;3-(1-pyrrolyl)pyridine;3-pyrrol-1-ylpyridine
• CAS NO: 72692-99-0
• Molecular Formula: C9H8N2
• Molecular Weight: 144.17
• Mol File: 72692-99-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 94 °C
• Flash Point: 113.1 °C
• Appearance: /
• Density: 1.06 g/cm³
• Vapor Pressure: 0.0168mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 3-(1H-PYRROL-1-YL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1H-PYRROL-1-YL)PYRIDINE(72692-99-0)
• EPA Substance Registry System: 3-(1H-PYRROL-1-YL)PYRIDINE(72692-99-0)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 72692-99-0(Hazardous Substances Data)

Usage

General Description

3-(1H-Pyrrol-1-yl)Pyridine, also known as C10H9N3, is an organic compound that belongs to the class of organic compounds known as pyridinyl-pyrrolopyrrolines. This group of compounds primarily consist of a pyridine ring that is fused to a pyrrole ring. In the specific case of 3-(1H-Pyrrol-1-yl)Pyridine, the nitrogen atom of the pyrrole ring is bound to the 3-position of the pyridine ring. It is similar to an azine and anarene, featuring a benzene-like ring attached to an azine. Additionally, it is a weak base, primarily existing in the non-ionized structure within an aqueous solution. As such, it typically exhibits neutral behavior when interacting with other substances and elements. Typically, it is a colorless liquid in atmospheric conditions, although certain environmental factors may cause variations in its state.

InChI:InChI=1/C9H8N2/c1-2-7-11(6-1)9-4-3-5-10-8-9/h1-8H

Upstream product

• 1120-90-7 3-iodopyridine 
• 109-97-7 pyrrole 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 462-08-8 pyridin-3-ylamine 
• 2530-26-9 3-nitropyridine 
• 6117-80-2 1,4-butenediol 
• 626-55-1 3-Bromopyridine 
• 526-99-8 meso-galactaric acid 

Downstream Products

• 144243-28-7 3-(pyrrolidin-1-yl)piperidine 
• 150281-46-2 3-(pyrrolidin-3-yl)pyridine 

Relevant articles and documents

Utilization of caffeine carbon supported cobalt catalyst in the tandem synthesis of pyrroles from nitroarenes and alkenyl diols

Employing bio-waste caffeine carbon-supported heterogeneous cobalt catalyst, synthesis of various substituted pyrrole derivatives is reported. In this methodology, pyrroles were synthesized through coupling between nitroarenes and alkenyl diols in a tandem manner. Among all the heterogeneous catalysts Co(OAc)2-CC-800 displayed the highest catalytic activity. Preparative scale synthesis of pyrroles and synthesis of anti-tubercular agent 5-(4-(1H-pyrrol-1-yl)phenyl)-1,3,4-oxadiazole-2-thiol revealed the practical applicability of this protocol. Several kinetic experiments and Hammett studies were conducted to understand the probable mechanism and electronic effects on this transformation.

Copper(I) Oxide/N,N′-Bis[(2-furyl)methyl]oxalamide-Catalyzed Coupling of (Hetero)aryl Halides and Nitrogen Heterocycles at Low Catalytic Loading

An easily prepared oxalic diamide is a powerful ligand for the copper-catalyzed coupling of aryl halides with nitrogen heterocycles. Only 1–2 mol% each of copper(I) oxide and N,N′-bis[(2-furyl)methyl]oxalamide (BFMO) are needed to form N-arylation products under mild conditions. More than 10 different types of nitrogen heterocycles are compatible with these conditions, thereby giving the corresponding N-arylation products. (Figure presented.).

Ligand-free Cu2O-catalyzed cross coupling of nitrogen heterocycles with iodopyridines

A practical and efficient strategy has been developed for the cross coupling of nitrogen heterocycles with halopyridines using ligand-free Cu 2O as catalyst and Cs2CO3 as the base. The protocol is applicable to a series of highly functionalised heterocycles, such as 7-azaindole, indazole, indole, imidazole, pyrrole and pyrazole, affording the N-heteroaryl derivatives in high yields (up to 96%).